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  • 1970-1974  (2)
  • 1
    Online Resource
    Online Resource
    Cover letter
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 4 ( 1970-01-01), p. 405-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 4 ( 1970-01-01), p. 405-
    Abstract: The rapid development of scaffold-based bone tissue engineering strongly relies on the fabrication of advanced scaffolds and the use of newly discovered functional drugs. As the creation of new drugs and their clinical approval often cost a long time and billions of U.S. dollars, producing scaffolds loaded with repositioned conventional drugs whose biosafety has been verified clinically to treat critical-sized bone defect has gained increasing attention. Carfilzomib (CFZ), an approved clinical proteasome inhibitor with a much fewer side effects, is used to replace bortezomib to treat multiple myeloma. It is also reported that CFZ could enhance the activity of alkaline phosphatase and increase the expression of osteogenic transcription factors. With the above consideration, in this study, a porous CFZ/ & beta;-tricalcium phosphate/poly lactic-co-glycolic acid scaffold (designated as & ldquo;cytidine triphosphate [CTP] & rdquo;) was produced through cryogenic three-dimensional (3D) printing. The hierarchically porous CTP scaffolds were mechanically similar to human cancellous bone and can provide a sustained CFZ release. The implantation of CTP scaffolds into critical-sized rabbit radius bone defects improved the growth of new blood vessels and significantly promoted new bone formation. To the best of our knowledge, this is the first work that shows that CFZ-loaded scaffolds could treat nonunion of bone defect by promoting osteogenesis and angiogenesis while inhibiting osteoclastogenesis, through the activation of the Wnt/ & beta;-catenin signaling. Our results suggest that the loading of repositioned drugs with effective osteogenesis capability in advanced bone tissue engineering scaffold is a promising way to treat criticalsized defects of a long bone.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    URL: Article
    DOI: 10.18063/ijb.v7i4.405
    DOI: 10.18063/ijb.v7i4.405.s182
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Supporting Information
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 4 ( 1970-01-01), p. 401-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 4 ( 1970-01-01), p. 401-
    Abstract: Recently, three-dimensional (3D) bioprinting technology is becoming an appealing approach for osteochondral repair. However, it is challenging to develop a bilayered scaffold with anisotropic structural properties to mimic a native osteochondral tissue. Herein, we developed a bioink consisting of decellularized extracellular matrix and silk fibroin to print the bilayered scaffold. The bilayered scaffold mimics the natural osteochondral tissue by controlling the composition, mechanical properties, and growth factor release in each layer of the scaffold. The in vitro results show that each layer of scaffolds had a suitable mechanical strength and degradation rate. Furthermore, the scaffolds encapsulating transforming growth factor-beta (TGF- & beta;) and bone morphogenetic protein-2 (BMP-2) can act as a controlled release system and promote directed differentiation of bone marrow-derived mesenchymal stem cells. Furthermore, the in vivo experiments suggested that the scaffolds loaded with growth factors promoted osteochondral regeneration in the rabbit knee joint model. Consequently, the biomimetic bilayered scaffold loaded with TGF- & beta; and BMP-2 would be a promising strategy for osteochondral repair.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.18063/ijb.v7i4.401
    DOI: 10.18063/ijb.v7i4.401.s177
    DOI: 10.18063/ijb.v7i4.401.s178
    DOI: 10.18063/ijb.v7i4.401.s179
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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