GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1970-1974  (62)
Material
Publisher
Person/Organisation
Language
Years
  • 1970-1974  (62)
Year
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Cover letter
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 4 ( 1970-01-01), p. 405-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 4 ( 1970-01-01), p. 405-
    Abstract: The rapid development of scaffold-based bone tissue engineering strongly relies on the fabrication of advanced scaffolds and the use of newly discovered functional drugs. As the creation of new drugs and their clinical approval often cost a long time and billions of U.S. dollars, producing scaffolds loaded with repositioned conventional drugs whose biosafety has been verified clinically to treat critical-sized bone defect has gained increasing attention. Carfilzomib (CFZ), an approved clinical proteasome inhibitor with a much fewer side effects, is used to replace bortezomib to treat multiple myeloma. It is also reported that CFZ could enhance the activity of alkaline phosphatase and increase the expression of osteogenic transcription factors. With the above consideration, in this study, a porous CFZ/ & beta;-tricalcium phosphate/poly lactic-co-glycolic acid scaffold (designated as & ldquo;cytidine triphosphate [CTP] & rdquo;) was produced through cryogenic three-dimensional (3D) printing. The hierarchically porous CTP scaffolds were mechanically similar to human cancellous bone and can provide a sustained CFZ release. The implantation of CTP scaffolds into critical-sized rabbit radius bone defects improved the growth of new blood vessels and significantly promoted new bone formation. To the best of our knowledge, this is the first work that shows that CFZ-loaded scaffolds could treat nonunion of bone defect by promoting osteogenesis and angiogenesis while inhibiting osteoclastogenesis, through the activation of the Wnt/ & beta;-catenin signaling. Our results suggest that the loading of repositioned drugs with effective osteogenesis capability in advanced bone tissue engineering scaffold is a promising way to treat criticalsized defects of a long bone.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    URL: Article
    DOI: 10.18063/ijb.v7i4.405
    DOI: 10.18063/ijb.v7i4.405.s182
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    cover letter
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 3 ( 1970-01-01), p. 364-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 3 ( 1970-01-01), p. 364-
    Abstract: Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. However, the construction of organoids currently faces numerous challenges, such as breakthroughs in scale size, vascularization, better reproducibility, and precise architecture in time and space. Recently, the application of bioprinting has accelerated the process of organoid construction. In this review, we present current bioprinting techniques and the application of bioinks and summarize examples of successful organoid bioprinting. In the future, a multidisciplinary combination of developmental biology, disease pathology, cell biology, and materials science will aid in overcoming the obstacles pertaining to the bioprinting of organoids. The combination of bioprinting and organoids with a focus on structure and function can facilitate further development of real organs.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    URL: Article
    DOI: 10.18063/ijb.v7i3.364
    DOI: 10.18063/ijb.v7i3.364.s156
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Coaxial Electrohydrodynamic Bioprinting of Pre-vascularized Cell-laden Constructs for Tissue Engineering
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 3 ( 1970-01-01), p. 362-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 3 ( 1970-01-01), p. 362-
    Abstract: Recapitulating the vascular networks that maintain the delivery of nutrition, oxygen, and byproducts for the living cells within the three-dimensional (3D) tissue constructs is a challenging issue in the tissue-engineering area. Here, a novel coaxial electrohydrodynamic (EHD) bioprinting strategy is presented to fabricate thick pre-vascularized cell-laden constructs. The alginate and collagen/calcium chloride solution were utilized as the outer-layer and inner-layer bioink, respectively, in the coaxial printing nozzle to produce the core-sheath hydrogel filaments. The effect of process parameters (the feeding rate of alginate and collagen and the moving speed of the printing stage) on the size of core and sheath lines within the printed filaments was investigated. The core-sheath filaments were printed in the predefined pattern to fabricate lattice hydrogel with perfusable lumen structures. Endothelialized lumen structures were fabricated by culturing the core-sheath filaments with endothelial cells laden in the core collagen hydrogel. Multilayer core-sheath filaments were successfully printed into 3D porous hydrogel constructs with a thickness of more than 3 mm. Finally, 3D pre-vascularized cardiac constructs were successfully generated, indicating the efficacy of our strategy to engineer living tissues with complex vascular structures.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    DOI: 10.18063/ijb.v7i3.362
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Changes of physicochemical properties and correlation analysis of common buckwheat starch during germination
    The Research Center of the Slovenian Academy of Sciences and Arts (ZRC SAZU) ; 1970
    In:  Fagopyrum Vol. 36, No. 2 ( 1970-01-01), p. 43-50
    Details
    In: Fagopyrum, The Research Center of the Slovenian Academy of Sciences and Arts (ZRC SAZU), Vol. 36, No. 2 ( 1970-01-01), p. 43-50
    Abstract: In order to clarify the physicochemical properties of starch during germination of common buckwheat, Xinong9976 was selected as the experimental material to study the main nutrients, particle structure, particle size distribution, transparency, aging value, pasting properties and the correlation between pasting properties and starch composition and main nutrients. The results showed that main nutrients were significantly different. The diameter of starch granules ranged from 2.36 to 8.89.m, and the shapes of starch granules were irregular with obvious holes and cracks on the surface. There were significant differences in starch transparency, aging value and pasting properties at different germination stages. Peak viscosity, through viscosity and final viscosity of germinated common buckwheat was significantly positive correlated with amylopectin content (P 〈 0.05) and breakdown, final viscosity and setback were significantly negatively correlated with amylose content (P 〈 0.05). The correlation analysis of starch pasting properties and main nutrients showed that breakdown, setback and crude fat content were significantly negatively correlated (P 〈 0.01), peak viscosity, through viscosity and final viscosity were significantly negatively correlated with crude fat content (P 〈 0.05), while the starch pasting properties had no significant correlation with other nutrients.Received: April 14, 2019; accepted: June 8, 2019Key words: common buckwheat, germination, physicochemical properties, starch
    Type of Medium: Online Resource
    ISSN: 0352-3020
    URL: Article
    DOI: 10.3986/fag0010
    Language: Unknown
    Publisher: The Research Center of the Slovenian Academy of Sciences and Arts (ZRC SAZU)
    Publication Date: 1970
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Highlight
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 1 ( 1970-01-01), p. 317-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 1 ( 1970-01-01), p. 317-
    Abstract: In this study, a & beta;-tricalcium phosphate ( & beta;-TCP)/poly (lactic-co-glycolic acid) (PLGA) bone tissue scaffold was loaded with osteogenesis-promoting drug HA15 and constructed by three-dimensional (3D) printing technology. This drug delivery system with favorable biomechanical properties, bone conduction function, and local release of osteogenic drugs could provide the basis for the treatment of bone defects. The biomechanical properties of the scaffold were investigated by compressive testing, showing comparable biomechanical properties with cancellous bone tissue. Furthermore, the microstructure, pore morphology, and condition were studied. Moreover, the drug release concentration, the effect of antituberculosis drugs in vitro and in rabbit radial defects, and the ability of the scaffold to repair the defects were studied. The results show that the scaffold loaded with HA15 can promote cell differentiation into osteoblasts in vitro, targeting HSPA5. The micro-computed tomography scans showed that after 12 weeks of scaffold implantation, the defect of the rabbit radius was repaired and the peripheral blood vessels were regenerated. Thus, HA15 can target HSPA5 to inhibit endoplasmic reticulum stress which finally leads to promotion of osteogenesis, bone regeneration, and angiogenesis in the rabbit bone defect model. Overall, the 3D-printed & beta;-TCP/PLGA-loaded HA15 bone tissue scaffold can be used as a substitute material for the treatment of bone defects because of its unique biomechanical properties and bone conductivity. & nbsp;
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.18063/ijb.v7i1.317
    DOI: 10.18063/ijb.v7i1.317.s135
    DOI: 10.18063/ijb.v7i1.317.s136
    DOI: 10.18063/ijb.v7i1.317.s137
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    STUDIES OF Be〈sup〉9〈/sup〉 (d,p), (d,t) AND (d,α) REACTIONS
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 1974
    In:  Acta Physica Sinica Vol. 23, No. 5 ( 1974), p. 64-
    Details
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 23, No. 5 ( 1974), p. 64-
    Abstract: The reactions of Be9(d, p0)Be10(0), Be9(d, p1)Be10(3.368 MeV), Be9(d, t0)Be8(0), Be9(d, α0)Li7(0) and Be9(d, α1) Li7 (0.478 MeV) have been studied at deuteron bombarding energies from 0.1 to 2.5 MeV. The angular distributions of these five groups of outgoing particles have been measured respectively between θL = 10°and 155°at eleven bombarding energies of 0.150, 0.220, 0.401, 0.706, 1.005, 1.301, 1.484, 1.750, 2.000, 2.250 and 2.500 MeV. The excitation functions of the Be9 (d,p0) Be10 reaction have been measured at θL = 135° from Ed = 0.1 to 2.5 MeV, at θL = 95° from Ed = 0.1 to 2.2 MeV and at θL = 112.5° from Ed, = 0.5 to 2.5 MeV, respectively. By use of thicker targets (100-300μg/cm2) and at Ed = 1.2 MeV, the absolute cross sections of the Be9(d, p0)Be10 reaction were measured at θL = 135°and 112.5°; the results obtained are: σ(p0)(θL = 135°)= 1.60 mb/st and σ(p0)(θL = 112.5°)=1.55 mb/st. Thus, the behaviours of the cross sections of all these five groups of outgoing particles have been obtained in this energy range. These experimental results are discussed to some extent.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    URL: Journal
    URL: Article
    DOI: 10.7498/aps
    DOI: 10.7498/aps.23.64
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 1974
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Radiation resistance of small electric and magnetic antennas in a cold uniaxial plasma
    Institute of Electrical and Electronics Engineers (IEEE) ; 1972
    In:  IEEE Transactions on Antennas and Propagation Vol. 20, No. 6 ( 1972-11), p. 796-798
    Details
    In: IEEE Transactions on Antennas and Propagation, Institute of Electrical and Electronics Engineers (IEEE), Vol. 20, No. 6 ( 1972-11), p. 796-798
    Type of Medium: Online Resource
    ISSN: 0096-1973
    URL: Article
    DOI: 10.1109/TAP.1972.1140320
    Language: English
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 1972
    detail.hit.zdb_id: 3132219-0
    detail.hit.zdb_id: 2027421-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Untitled
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 3 ( 1970-01-01), p. 359-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 3 ( 1970-01-01), p. 359-
    Abstract: The pathological research and drug development of brain diseases require appropriate brain models. Given the complex, layered structure of the cerebral cortex, as well as the constraints on the medical ethics and the inaccuracy of animal models, it is necessary to construct a brain-like model in vitro. In this study, we designed and built integrated three-dimensional (3D) printing equipment for cell printing/culture, which can guarantee cell viability in the printing process and provide the equipment foundation for manufacturing the layered structures with gradient distribution of pore size. Based on this printing equipment, to achieve the purpose of printing the layered structures with multiple materials, we conducted research on the performance of bio-inks with different compositions and optimized the printing process. By extruding and stacking materials, we can print the layered structure with the uniform distribution of cells and the gradient distribution of pore sizes. Finally, we can accurately print a structure with 30 layers. The line width (resolution) of the printed monolayer structure was about 478 & mu;m, the forming accuracy can reach 97.24%, and the viability of cells in the printed structure is as high as 94.5%.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    URL: Article
    DOI: 10.18063/ijb.v7i3.359
    DOI: 10.18063/ijb.v7i3.359.s155
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Multi-target UAV miniature staring hyperspectral imager radiation correction
    EnPress Publisher ; 1970
    In:  Imaging and Radiation Research Vol. 2, No. 1 ( 1970-01-01), p. 32-
    Details
    In: Imaging and Radiation Research, EnPress Publisher, Vol. 2, No. 1 ( 1970-01-01), p. 32-
    Abstract: The micro staring hyperspectral imager can simultaneously acquire two spatial and one spectral images, and only record the external orientation elements of the entire hyperspectral image rather than the external orientation elements of each frame of the image, which avoids the geometric instability during scanning, effectively solves the problem of large geometric deformation of the small line scanning hyperspectral imager, and is suitable for the small UAV load platform with unstable attitude. At present, most of the research focuses on the radio-metric correction method of line scan hyperspectral imager. The application time of staring hyperspectral imager is short, and there is no mature data processing re-search at home and abroad, which hinders the application of UAV micro staring hyperspectral imaging system. In this paper, the calibration method of the linearity and variability of the radiation response of the micro staring hyperspectral imager on the UAV is studied, and the effectiveness of this method is quantitatively evaluated. The results show that the hyperspectral image has obvious vignetting effect and strip phenomenon before the correction of radiation response variability. After the correction, the radiation response variation coefficient of pixels in different bands decreases significantly, and the vignetting effect and image strip decrease significantly. In this paper, a multi-target radiometric calibration method is proposed, and the accuracy of radiometric calibration is verified by comparing the calibrated hyperspectral image spectrum with the measured ground object spectrum of the ground spectrometer. The results show that the calibration results of the multi-target radiometric calibration method show better results, especially for the near-infrared band, and the difference with the surface reflectance measured by the spectrometer is small.
    Type of Medium: Online Resource
    ISSN: 2578-1618
    URL: Issue
    URL: Article
    DOI: 10.24294/irr.v2i1
    DOI: 10.24294/irr.v2i1.1718
    Language: Unknown
    Publisher: EnPress Publisher
    Publication Date: 1970
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Green's-function diagrammatic technique for complicated level systems
    American Physical Society (APS) ; 1974
    In:  Physical Review B Vol. 10, No. 11 ( 1974-12-1), p. 4714-4723
    Details
    In: Physical Review B, American Physical Society (APS), Vol. 10, No. 11 ( 1974-12-1), p. 4714-4723
    Type of Medium: Online Resource
    ISSN: 0556-2805
    URL: Article
    DOI: 10.1103/PhysRevB.10.4714
    RVK:
    UA 6500.3.B
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 1974
    detail.hit.zdb_id: 2844160-6
    detail.hit.zdb_id: 209770-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...