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  • 1970-1974  (2)
  • 1
    Online Resource
    Online Resource
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 4 ( 1970-01-01), p. 405-
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 4 ( 1970-01-01), p. 405-
    Abstract: The rapid development of scaffold-based bone tissue engineering strongly relies on the fabrication of advanced scaffolds and the use of newly discovered functional drugs. As the creation of new drugs and their clinical approval often cost a long time and billions of U.S. dollars, producing scaffolds loaded with repositioned conventional drugs whose biosafety has been verified clinically to treat critical-sized bone defect has gained increasing attention. Carfilzomib (CFZ), an approved clinical proteasome inhibitor with a much fewer side effects, is used to replace bortezomib to treat multiple myeloma. It is also reported that CFZ could enhance the activity of alkaline phosphatase and increase the expression of osteogenic transcription factors. With the above consideration, in this study, a porous CFZ/ & beta;-tricalcium phosphate/poly lactic-co-glycolic acid scaffold (designated as & ldquo;cytidine triphosphate [CTP] & rdquo;) was produced through cryogenic three-dimensional (3D) printing. The hierarchically porous CTP scaffolds were mechanically similar to human cancellous bone and can provide a sustained CFZ release. The implantation of CTP scaffolds into critical-sized rabbit radius bone defects improved the growth of new blood vessels and significantly promoted new bone formation. To the best of our knowledge, this is the first work that shows that CFZ-loaded scaffolds could treat nonunion of bone defect by promoting osteogenesis and angiogenesis while inhibiting osteoclastogenesis, through the activation of the Wnt/ & beta;-catenin signaling. Our results suggest that the loading of repositioned drugs with effective osteogenesis capability in advanced bone tissue engineering scaffold is a promising way to treat criticalsized defects of a long bone.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
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  • 2
    Online Resource
    Online Resource
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 3 ( 1970-01-01), p. 377-
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 3 ( 1970-01-01), p. 377-
    Abstract: A hydrogel that combines both printability and adaptability, high elasticity, and stretchability can provide ideal mechanical properties, and also render complex and accurate construction for ionic skin. However, it is extremely challenging. Here, we propose a colloidal-based double-network (DN) hydrogel as printable inks for high-precision fabrication of ionic skins. Particularly, polyacrylamide (PAAm), as the covalent network that can maintain the long-term material integrity, was combined with gelatin colloidal network to improve the injectability and printability of the resulting DN hydrogels. The DN design cooperatively provides the hydrogels with higher toughness values and deformability than what single colloidal or PAAm network can achieve. Further design of ionic skin based on capacitor microarray was demonstrated to serve as a sensitive and stable capacitor that can respond to external stimuli, thereby allowing to sense the body movements such as finger bending, laugh, and wrist pulse by translating mechanical changes into electric signals. Therefore, this study provides a novel strategy for the design and preparation of high-resolution ionic skins as the wearable sensor.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
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