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  • 1970-1974  (6)
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  • 1970-1974  (6)
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  • 1
    Online Resource
    Online Resource
    IMMUNOREACTIVE GROWTH HORMONE IN PLASMA AND URINE IN LONG TERM INSULIN TREATED DIABETICS IN RELATION TO DIABETIC RETINOPATHY
    Oxford University Press (OUP) ; 1974
    In:  Acta Endocrinologica Vol. 75, No. 1 ( 1974-01), p. 64-74
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 75, No. 1 ( 1974-01), p. 64-74
    Abstract: In 15 long term insulin dependent diabetics with a normal excretion of albumin in the urine ( 〈 25 mg/24 h), plasma immunoreactive growth hormone (IRHGH) was measured serially together with the urinary immunoreactive growth hormone (IRHGH) during 24 hours. A positive correlation was shown between mean plasma IRHGH and urinary IRHGH in the individual patient (0.05 〉 P 〉 0.02). No significant difference between median plasma IRHGH in the diabetics and controls was observed. However, urinary IRHGH was higher in the diabetics than in the controls (0.05 〉 P 〉 0.02). A near positive correlation was shown between urinary IRHGH and glucosuria (R = 0.50, 0.1 〉 P 〉 0.05). No correlation was shown between the degree of diabetic retinography and the mean plasma IRHGH or urinary IRHGH.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.0750064
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1974
    detail.hit.zdb_id: 1485160-X
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    Online Resource
  • 2
    Online Resource
    Online Resource
    IMMUNOREACTIVE GROWTH HORMONE IN PLASMA AND URINE IN JUVENILE DIABETICS BEFORE AND DURING INITIAL INSULIN TREATMENT
    Oxford University Press (OUP) ; 1974
    In:  Acta Endocrinologica Vol. 75, No. 1 ( 1974-01), p. 50-63
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 75, No. 1 ( 1974-01), p. 50-63
    Abstract: Twenty newly diagnosed, but as yet untreated patients of both sexes with classical juvenile diabetes were investigated by determining the mean plasma immunoreactive growth hormone (IRHGH) and urinary IRHGH for a 24 hour period before and during initial insulin treatment. The plasma IRHGH was significantly higher (0.05 〉 P 〉 0.01) before than during initial insulin treatment. During initial insulin treatment, the mean plasma IRHGH was significantly higher (0.01 〉 P 〉 0.001) than in a control group. The urinary IRHGH was significantly higher (0.01 〉 P 〉 0.001) before than during insulin treatment. The increased urinary IRHGH observed before insulin treatment is thought to be partly due to a defective renal tubular reabsorption of growth hormone. No significant correlation was found between the mean blood sugar and plasma or urinary IRHGH either before or during insulin treatment.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.0750050
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1974
    detail.hit.zdb_id: 1485160-X
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  • 3
    Online Resource
    Online Resource
    A GROWTH HORMONE FACTOR IN HUMAN URINE
    Oxford University Press (OUP) ; 1971
    In:  Acta Endocrinologica Vol. 68, No. 1_Supplb ( 1971-12), p. S202-
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 68, No. 1_Supplb ( 1971-12), p. S202-
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.067S202
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1971
    detail.hit.zdb_id: 1485160-X
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  • 4
    Online Resource
    Online Resource
    URINARY GROWTH HORMONE IN ACROMEGALY
    Wiley ; 1974
    In:  Acta Medica Scandinavica Vol. 195, No. 1-6 ( 1974-01-12), p. 381-384
    Details
    In: Acta Medica Scandinavica, Wiley, Vol. 195, No. 1-6 ( 1974-01-12), p. 381-384
    Abstract: Abstract. Urinary growth hormone compared to plasma growth hormone during peroral glucose tolerance test has been studied in 16 patients with clinically obvious acromegaly. The urinary excretion of growth hormone was clearly elevated in all patients with acromegaly when compared to a normal group. One of the patients with established acromegaly had normal fasting plasma growth hormone levels, but urinary growth hormone was grossly elevated. No significant correlation was found between plasma and urinary growth hormone in the individual patient. Neither plasma nor urinary growth hormone were well correlated to the clinical activity of the disease. It is concluded that measurement of urinary growth hormone is a valuable tool in the diagnosis of acromegaly. The measurement might be of special interest in the early period of acromegaly before the disfiguring changes have taken place in the patients.
    Type of Medium: Online Resource
    ISSN: 0001-6101
    URL: Issue
    URL: Article
    DOI: 10.1111/joim.1974.195.issue-1-6
    DOI: 10.1111/j.0954-6820.1974.tb08156.x
    Language: English
    Publisher: Wiley
    Publication Date: 1974
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  • 5
    Online Resource
    Online Resource
    IMMUNOREACTIVE GROWTH HORMONE IN HUMAN URINE
    Oxford University Press (OUP) ; 1972
    In:  Acta Endocrinologica Vol. 71, No. 4 ( 1972-12), p. 665-676
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 71, No. 4 ( 1972-12), p. 665-676
    Abstract: By using a double antibody radio-immunoassay (pre-precipitation technique) for the determination of immunoreactive human growth hormone (IRHGH) in normal human urine concentrated by dialysis and lyophilization, a factor was revealed that displaces 125 I-HGH from HGH antibodies. This displacement was neither due to salts nor to glucose; it is suggested that it is due to IRHGH in the urine. A linear relationship between dilution of urine and the measured IRHGH concentration was obtained. Recovery of exogenous HGH was between 70–105%. The recovery of IRHGH from different volumes of urine following dialysis and lyophilization was between 97–110%. Plasma IRHGH and urinary IRHGH was measured simultaneously after HGH injection in a normal subject. A correlation was shown between plasma IRHGH and urinary IRHGH. In 9 normal subjects, the urinary IRHGH ranged from 28–53 ng/24 h. The excretion of urinary IRHGH was increased in acromegaly and was diminished in some, but not in all patients with adult hypopituitarism. The urinary IRHGH was further studied by gel filtration. It was recovered in one peak corresponding to a molecular weight of approximately 20 000 – 30 000. However, in the present work it was not clarified whether the urinary IRHGH represents pituitary HGH excreted in the urine or a metabolite of high molecular weight with retained immunological properties.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.0710665
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1972
    detail.hit.zdb_id: 1485160-X
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  • 6
    Online Resource
    Online Resource
    RADIOIMMUNOASSAY OF GROWTH HORMONE IN HUMAN PLASMA
    Oxford University Press (OUP) ; 1972
    In:  Acta Endocrinologica Vol. 71, No. 4 ( 1972-12), p. 649-664
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 71, No. 4 ( 1972-12), p. 649-664
    Abstract: The double antibody radio-immunoassay (pre-precipitation technique) for immunoreactive growth hormone (IRHGH) in human plasma has been evaluated on the basis of dilution and recovery experiments as well as by the investigation of accuracy and reproducibility. Given optimal conditions for the precipitation reaction, the method seems suitable for determination of plasma IRHGH. No cross-reaction between the precipitating antiserum and human gammaglobulin was demonstrated. Furthermore, by using an incubation period of 6 days for the reaction between 125 I-HGH and the precipitated HGH antibodies, no serum factor influencing this reaction could be demonstrated. The results of the plasma IRHGH determinations were shown to be independent of the percentage of the radioactive degradation products present in the tracer HGH. The lower detection limit is better than 0.39 ng/ml. The cumulated within-assay coefficient of variation was between 4–7% and the cumulated between-assay coefficient of variation 10%. By using gel filtration, IRHGH in the plasma was shown to be nonhomogeneous when considering molecular weight. The normal fasting values in the ambulatory state was (Mean ± sd ) ng/ml: Men 1.48 ± 0.33; women 3.83 ± 3.47. During the insulin tolerance test the mean peak plasma IRHGH was lower in children than in adults (0.02 〉 P 〉 0.01). It is suggested that this is due to the influence of sex steroids in adult subjects.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.0710649
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1972
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
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    Online Resource
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