ISSN:
1432-2072
Keywords:
Sleep
;
Desynchronized Sleep
;
Alpha-Methylparatyrosine
;
Catecholamines
;
Norepinephrine
;
D-State or D-Sleep
;
REM-Sleep
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract l-Alpha-methylparatyrosine administered orally in doses of 50, 75 and 100 mg/kg produced a significant increase in desynchronized sleep time (D-time) in the rat. However, 75 mg/kg of l-AMPT, administered intraperitoneally resulted in disturbed sleep and reduced D-time; this may explain some discrepancies in previous studies. Over a 24-h period, the time of maximum increase in D-time after oral l-AMPT coincided closely with the time of maximum decrease in brain norepinephrine levels; both occurred 7–10 h after drug administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00572273
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