ISSN:
1573-8744
Keywords:
Michaelis-Menten kinetics
;
dose-dependent kinetics
;
one-compartment model
;
two-compartment model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Throughout the literature, enzyme constants have been derived by utilizing in vivodata and indirectly assuming that these data were described by the one-compartment open model. However, many drugs are probably best described by a two-compartment open model with Michaelis-Menten elimination kinetics. Simulated data, which obey the two-compartment open model with Michaelis-Menten elimination, and which illustrate some of the interesting properties of such models, are presented. Treatment of two-compartment data by one-compartment analysis is shown to result in a serious distortion of enzyme parameters (V m ,K m ).For data which obey the two-compartment open model, estimation of the Michaelis-Menten constant (K m )and the maximum velocity (V m )by one-compartment analysis cannot be theoretically justified and therefore should be avoided.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01061506
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