ISSN:
1432-2013
Keywords:
Renal Tubule
;
Microperfusion
;
Cystine Reabsorption
;
Arginine Reabsorption
;
Cystinuria Pathogenesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In microperfusion experiments the reabsorption of14C-labelledl-cystine,l-cysteine, andl-arginine from rat proximal tubule was measured, and the transport interaction of these amino acids and some derivatives was tested. The following results were obtained: 1. l-arginine,l-lysine, andl-cysteine inhibitedl-cystine reabsorption. 2. Glycine, agmantine, and 2,6-diaminopimelic acid showed no influence onl-cystine reabsorption. 3. l-cysteine reabsorption was inhibited byl-arginine, but not by glycine. 4. l-cysteine and 2,6-diaminopimelic acid were unable to influence reabsorption ofl-arginine. From these results and some observations reported in the literature, the following concept is put forward for discussion.l-arginine,l-lysine andl-ornithine may be reabsorbed by two separate mechanisms in the proximal tubule.l-cystine may use only one of these ways. Here, it is possible thatl-cystine is transported asl-cysteine. This concept may find relevance in the explanation of the pathogenesis of cystinuria.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00586645
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