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  • 1975-1979  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Epidermal abnormalities in Refsum's disease (1977)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 97 (1977), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A female patient with severe Refsum's disease is described. She had striking ichthyosis and detailed investigations into the structure of the epidermis were performed. Light microscopy and transmission electron microscopy revealed lipid-containing vacuoles in the epidermis. Scanning electron microscopy of the stratum corneum showed disruption and the presence of microvilli on individual horn cells consistent with a high output state of epidermal cell production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1977.tb14248.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of transmissible gastroenteritis virus neutralising antibody in cats (1977)
    Springer
    Archives of virology 55 (1977), S. 77-86 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary High titres of neutralising activity to transmissible gastroenteritis virus (TGEV), a porcine coronavirus, were found in sera and peritoneal fluids from cats infected with feline infectious peritonitis (FIP). A small proportion of cats, from a hospital population unaffected by FIP, also had neutralising activity. Procedures to remove non-specific viral inhibitors, including treatment by heat inactivation, trypsin, sulphydryl reagent and kaolin absorption were unsuccessful. The active component was unable to neutralise another porcine coronavirus, haemagglutinating encephalomyelitis virus or the porcine enterovirus, Talfan. Gel filtration of feline sera and peritoneal fluid demonstrated high levels of the neutralising activity in the area corresponding to 7S IgG, which could be removed by absorption with specific anti-IgG serum and these properties are suggested to be consistent with those of antibody. These findings imply that there is a coronavirus in cats which is antigenically related to TGEV and its possible nature is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314481
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Virus isolation and serum antibody responses after infection of cats with transmissible gastroenteritis virus (1979)
    Springer
    Archives of virology 60 (1979), S. 161-166 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transmissible gastroenteritis virus was administered orally to cats. No clinical disease resulted but infectious virus was isolated from faeces for up to 22 days after infection and serum antibody was detected by neutralisation and immunofluorescence tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01348032
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A longitudinal study of the serological and virological status of 18 women infected with cytomegalovirus (1978)
    Springer
    Archives of virology 58 (1978), S. 111-118 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 18 women, of known seropositivity, have been followed for between 18 and 66 months (mean 50.2 months) for viral excretion and serological changes. CMV was isolated from 58/146 (39.7 per cent) cultures from various sites, mostly cervix. A total of 129 sera were obtained and each was titrated in the late antigen, early antigen and anti-complement immunofluorescence assays, as well as the complement fixation and microneutralisation tests. From 3 women virus was consistently re-isolated, from 3 others virus was never re-isolated and the remaining 12 women excreted virus intermittently during the period of study. No significant changes in antibody titres could be detected by any of the 5 serological assays in any woman during periods of viral excretion. This suggests that local reactivation of latent CMV infection is not associated with a demonstrable systemic antibody response. Inter-assay correlations were sought for each of the 10 possible combinations of pairs of tests. Significant correlations were found for most pairs of tests, with the notable exception of those involving the early antigen test. This confirms that antibodies detected in this assay are distinct from those detected by the other 4 serological assays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315403
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Generation of virus-specific cytolytic activity in human peripheral lymphocytes after vaccination with vaccinia virus and measles virus (1978)
    Springer
    Medical microbiology and immunology 166 (1978), S. 71-79 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human peripheral blood lymphocytes (PBL) harvested after vaccination with vaccinia or measles virus showed a specific activity against virusinfected target cells. This activity peaked on day 7 and was specific for the target cells infected with the virus used for the vaccination. The cytotoxic activity was not related to HLA markers. The cells involved in the cytolytic process were lymphocytes bearing Fc receptors. In addition, the cytotoxic activity was abrogated by more than 90% by rabbit Fab'2 anti-human IgG. It is therefore likely that two subpopulations of lymphocytes are involved: an antibody-secreting cell providing specific antiviral antibody and an effector cell bearing Fc receptor (K cells). Finally, these experiments suggest that antibody-dependent cell cytotoxicity may play a major role in the recovery from virus infection in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02121136
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