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  • 1975-1979  (2)
Document type
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    The effect of polycyclic hydrocarbons on the synthesis of DNA in lymphoid organs, bone marrow and regenerating rat liver (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 358-360 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto È esaminato l'effetto di sette idrocarburi policiclici, a diverso potere oncogeno, sulla sintesi del DNA nel timo, milza, midollo e fegato rigenerante di ratto. Il DMBA è inibente in tutti i tessuti esaminati, come pure il 1,2,3,4-DBA. Il BP ha un notevole effetto solo sul fegato rigenerante mentre il 1,2,3,4-DBA é più efficace dell'1,2,5,6-DBA in ogni caso. Non é stata stabilita una correlazione tra il potere oncogeno delle sostanze esaminate e la inibizione della sintesi del DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922585
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of urethan on the synthesis of nucleic acids in thymus, spleen, and bone marrow (1975)
    Springer
    Journal of cancer research and clinical oncology 84 (1975), S. 281-289 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Urethan, in a single dose of 1 mg/g body weight, exerts a strong inhibitory effect on DNA synthesis in lymphoid organs and bone marrow of rat. The inhibition observed in spleen and thymus is longer lasting than that exerted on bone marrow or regenerating liver, demonstrating a marked sensitivity of lymphoid cells to the drug. This effect can explain the rapid reduction of weight and cell number in thymus and spleen under urethan treatment, in absence of any lymphocytolytic action. The different effect of urethan on the different subpopulations of lymphoid cells therefore appears to be due to their kinetics rather than to a specific sensitivity of some of them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312249
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    Paper (German National Licenses)
    Fulltext
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