Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
8 (1978), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In studies of the cellular localization of AFP with the use of immunofluorescent, immunochemical and immunoautoradiographic techniques we concentrated in the course of prenatal ontogeny of pigs on the mesenchymal haemopoictic population of lymphatic and haemopoietic organs of these animal species. A marked AFP positivity was demonstrated already in haemopoietic cells of yolk sac, but also in other organs of embryonic and fetal haemopoiesis. In the course of intrauterine development the percentage of AFP-positive haemopoietic cells decreases and postnatally the AFP positivity of haemopoietic cells does not occur. The decrease in AFP-positivity of haemopoietic fetal cells is in correlation with the subsequent decrease in the intensity of extramedullary haemopoiesis. In the system in vitro the inhibitory effect of pig AFP on T and B cell mitogen-induced blast transformation of lymphocytes was demonstrated, similarly as on the mixed lymphocyte reaction. That effect of AFP is dependent on its presence in the first 24 hrs of stimulation and is not species specific. In fetal cell suspensions of lymphatic and haemopoietic organs of pigs their capacity for blastogenic transformation with anti-AFP serum was demonstrated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1978.tb03933.x
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