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Dopamine-like effects of cholera toxin in the central nervous system (1975)

MILLER, RICHARD J. ; KELLY, PETER H.

[s.l.] : Nature Publishing Group

Nature 255 (1975), S. 163-166

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Cannulae were implanted bilaterally into the nucleus accumbens septi (NAS) of adult male Sprague-Dawley rats and choleragen (1 Atg in l/il) or 1 p\ of vehicle was injected. To distinguish between possible pre- or postsynaptic effects of the toxin on dopaminergic mechanisms, a further group of ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/255163a0

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The enkephalins (1978)

Miller, Richard J. ; Cuatrecasas, Pedro

Springer

Naturwissenschaften 65 (1978), S. 507-514

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ISSN: 1432-1904

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General

Notes: Abstract Two penta-peptides with morphine-like properties have recently been found in the nervous system and gastrointestinal tract. These peptides known as enkephalins are unevenly distributed in the brain, the highest concentration being in the globus pallidus. The enkephalins are found to have analgesic properties and are also anti-tussive, anti-diarrheal and able to stimulate release of prolactin and growth hormone. Synthetic analogues of the enkephalins containing specific D-amino acid substitutions have been developed and show a wide spectrum of activities.