GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Neuropharmacology : Studies of Narcotic Drugs. (1975)
    San Diego :Elsevier Science & Technology,
    Details
    Keywords: Narcotics. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (65 pages)
    Edition: 1st ed.
    ISBN: 9781483140001
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1604022
    Language: English
    Note: Front Cover -- Neuropharmacology -- Copyright Page -- CHAPTER 1. CHOLINERGIC MECHANISMS IN NARCOTICANALGESICS -- REFERENCES -- CHAPTER 2. THE USE OF AMINE FLUORESCENCEHISTOCHEMISTRY IN THE STUDY OF DRUGS,ESPECIALLY MORPHINE, ON THE CNS -- REFERENCES -- CHAPTER 3. EFFECT OF METHADONE AND DEXTROMORAMIDEON DOPAMINE METABOLISM: COMPARISON WITHHALOPERIDOL AND AMPHETAMINE -- EFFECT ON ADENYLATE CYCLASE -- CONCLUSIONS -- REFERENCES -- CHAPTER 4. PREDICTIVE VALUES OF PHARMACOLOGICALMODELS TO STUDY OPIATE DEPENDENCE -- REFERENCES -- CHAPTER 5. ACTION OF OPIATES, ANTIPSYCHOTICS,AMPHETAMINE AND APOMORPHINE ON DOPAMINERECEPTORS IN RAT STRIATUM: IN VIVO CHANGES OF3,5-CYCLIC AMP CONTENT AND ACETYLCHOLINETURNOVER RATE -- INTRODUCTION -- EXPERIMENTAL STUDIES -- REFERENCES -- CHAPTER 6. STRUCTURAL FEATURES ASSOCIATED WITHNARCOTICS AND NARCOTIC ANTAGONISTS -- REFERENCES.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    GEOMAR EBL
  • 2
    Electronic Resource
    Electronic Resource
    PHOSPHOPROTEIN PHOSPHATASE OF PINEAL GLAND: SOME PROPERTIES OF THE ENZYME AND THE IDENTIFICATION OF AN ENDOGENOUS ACTIVATOR (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Both soluble and insoluble fractions of rat pineal glands catalyze the dephosphorylation of phosphohistone. The phosphoprotein phosphatase in cytosol as well as in insoluble fraction is inhibited by ZnCl2 and NaF. Guanosine triphosphate, ATP and MnCl2 activate the soluble enzyme but not the enzyme in the insoluble fraction suggesting that with solubilization from membranes some unfunctional changes of the enzyme may occur. Fractionation of the soluble enzyme preparation revealed the existence of two forms of enzyme differing in molecular weight. These two forms can be further differentiated by their sensitivities to MnCl2 and deoxycholate. A thermostable factor which activates the soluble but not the insoluble enzyme was demonstrated in both beef and rat pineal glands. The thermostable factor is protein in nature because it is nondialyzable and trypsin labile. Whether in vivo the endogenous activator mediates the regulation of the phosphoprotein phosphatase in pineal remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb10671.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    CATECHOLAMINES IN SYMPATHETIC GANGLIA OF RAT: EFFECTS OF DEXAMETHASONE AND RESERPINE (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 24 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The superior cervical sympathetic ganglion of rats contains a finite amount of epinephrine all of which is of ganglionic origin. Treatment of new-born rats with dexamethasone for 8 days results in a 112-fold increase in the epinephrine concentration, whereas the norepinephrine and dopamine are increased by only 1·4- and 1·9-fold respectively. This epinephrine increase in newborn rats is reversible if treatment is discontinued, and it fails to occur in adult animals. The epinephrine store of normal and dexamethasone treated animals is resistant to the depletion by reserpine. There is no increase in the epinephrine content in organs innervated by axons emanating from the ganglion. The data presented support the localization of epinephrine in small intensely fluorescent cells in the ganglion and we propose that epinephrine may be released from these cells and function as a modulator of ganglionic transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb11876.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    ALTERATIONS IN GABA METABOLISM AND MET-ENKEPHALIN CONTENT IN RAT BRAIN FOLLOWING REPEATED ELECTROCONVULSIVE SHOCKS (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of electroconvulsive shock (ECS; 120 V for 1 s through ear-clip electrodes) or sub-convulsive shocks (70 V for 1 s) on rat brain GABA and met-enkephalin concentration and GABA turnover has been examined 24 h after a single treatment (×1) or once daily for 10 days (×10). ECS × 10 increased GABA concentrations in the N. caudatus and N. accumbens and decreased the synthesis rate of GABA by 40% and 50% respectively in these regions. Sub-convulsive shocks (× 10 × 10) or ECS × 1 had no effect. No consistent changes were seen in the substantia nigra. Met-enkephalin concentrations increased by 50% in the N. caudatus after ECS × 10 but were unchanged in the cortex and pons/medulla. No other shock regimen had any effect on the concentration of this peptide. The results are discussed in relation to the enhanced monoamine-induced responses seen only after ECS × 10.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb07831.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    MODULATION OF THE TURNOVER RATE OF ACETYLCHOLINE IN RAT BRAIN BY INTRAVENTRICULAR INJECTIONS OF THYROTROPIN-RELEASING HORMONE, SOMATOSTATIN, NEUROTENSIN AND ANGIOTENSIN II (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The turnover rate of acetylcholine (TRACh) was measured in frontal and parietal cortex striatum, hippocampus, diencephalon and brain stem following the intraventricular injection of thyrotropin-releasing hormone (TRH), somatostatin, neurotensin and angiotensin II. These peptides selectively change the TRACh of various brain regions suggesting specific and independent actions. This specificity of action was also tested by injecting L-prolylglycine, poly-L-proline and poly-L-glutamate. None of these synthetic peptides affect the TRACh. TRH increases the TRACh in parietal but not in frontal cortex whereas somatostatin, neurotensin and angiotensin II failed to change the TRACh in these cortical areas. Somatostatin and neurotensin increase the TRACh in diencephalon, whereas TRH and angiotensin II do not. All four peptides decrease the acetylcholine (ACh) content of parietal cortex but not that of frontal cortex. Only somatostatin changes the TRACh in pons medulla. Larger doses of TRH, neurotensin and angiotensin II fail to elicit greater or more general changes in TRACh. In contrast, high doses of somatostatin increase the TRACh of hippocampus and induce‘barrel’rotation. Intraseptal injections of somatostatin induce a long lasting catalepsy but fail to change hippocampal TRACh or to elicit‘barrel’rotation
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb07841.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    POSSIBLE DEFECT IN CHOLINERGIC NEURONS OF MUSCULAR DYSTROPHIC MICE (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 24 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The cholinoacetyltransferase activity (CAT) in diaphragm of mice of Bar Harbor strain (129 ReJ dy/dy) with muscular dystrophy was significantly lower than that of phenotypically normal litter mates (129 ReJ dy/+). CAT, tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DβH) activities were found identical in adrenal gland and brain homogenates of normal and dystrophic mice. Subacute injections of atropine (72 μmol/kg i. p., twice daily for 3 days) failed to increase the activity of adrenal CAT in dystrophic mice but increased this enzyme activity in adrenals of normal litter mates. The concentration in brain of dopamine, norepinephrine, serotonin, acetylcholine (ACh), γ-aminobutyric acid (GABA) and some of their precursors were measured. Only the concentration of ACh was significantly lower in the brain of muscular dystrophic mice. The rate of accumulation of brain ACh concentration after the injection of oxotremorine (5μmol/kg i. p.) is slower in muscular dystrophic animals than in normal litter mates. Furthermore, the turnover rate of ACh in total brain was slower in muscular dystrophic mice than in phenotypically normal litter mates. The turnover rate of brain dopamine and norepinephrine in these 2 groups of animals was similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb07656.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Pharmacological Implications of Brain Acetylcholine Turnover Measurements in Rat Brain Nuclei (1977)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 17 (1977), S. 369-386 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.17.040177.002101
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Molecular Mechanisms in the Receptor Action of Benzodiazepines (1979)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 19 (1979), S. 531-545 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.19.040179.002531
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Decreased content of immunoreactive enkephalin-like peptide in peripheral tissues of spontaneously hypertensive rats (1979)
    [s.l.] : Nature Publishing Group
    Nature 278 (1979), S. 646-647 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 The content of ME- and LE-like material in various tissues of WKY and SHR rats Superior cervical Salivary Adrenal Rat Rat age Coeliac ganglion ganglion gland gland Hypothalamus strain (weeks) ME LE ME ME ME ME WKY 4 3.4±0.31 1.8±0.097 1.9±0.12 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/278646a0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain (1978)
    [s.l.] : Nature Publishing Group
    Nature 275 (1978), S. 553-555 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Any known transmitter, including GABA, fails to compete with the benzodiazepines for their specific brain receptors; however, the brain distribution pattern of these benzodiazepine receptors is similar to that of the Na+-independent high affinity binding sites for GABA (8.9). This and analogies in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/275553a0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...