In:
Proceedings, annual meeting, Electron Microscopy Society of America, Cambridge University Press (CUP), Vol. 35 ( 1977), p. 506-507
Abstract:
Information concerning cell structure and function during riboflavin deficiency is important in view of the finding that treatment of human neoplasms such as lymphosarcoma and Hodgkin's disease with a riboflavin deficient regime and galactoflavin, a riboflavin antagonist, induces partial remission (1). Results from the present study indicate that riboflavin deficiency severely affects the structural integrity of myelin lamellae (Fig. 1). The myelin sheath undergoes a form of dissociation or separation, in essence a pulling apart of adjacent membranes. In addition, there are marked degrees of fragmentation not only of the myelin membranes but also of the axolemma. These results correlate well with clinical data which reveal that various sensory and motor pathways are adversely affected by a riboflavin-deficient diet (2). The riboflavin deficiency produces no discernible effects upon organelle content of neurons. Organization and integrity of microtubules, neurofilaments and mitochondria are maintained at least until fragmentation of the axolemma occurs. Nonmyelinated nerve fibers do not appear to be affected ultrastructurally by the deficiency.
Type of Medium:
Online Resource
ISSN:
0424-8201
,
2690-1315
DOI:
10.1017/S0424820100079966
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
1977
SSG:
11
Permalink