In:
The Journal of Immunology, The American Association of Immunologists, Vol. 122, No. 6 ( 1979-06-01), p. 2458-2464
Abstract:
Recent studies have indicated that the inability of UV-irradiated mice to reject UV-induced fibrosarcomas is, at least in part, due to the presence of suppressor T lymphocytes. These cells appear to exert their influence by inhibiting the functional development of effector cells with specificity for cross-reactive tumor-associated antigens. In these experiments, we present evidence as to the nature of the cell types involved in the immunologic responses elicited against UV-induced tumors. The effector cells capable of establishing a state of tumor immunity are T lymphocytes that appear to lack demonstrable Ia determinants. The regulatory suppressor cells, previously shown to be T lymphocytes, have been determined to be Ia+ and functionally radiosensitive. The in vivo administration of anti-Ia antibody or the exposure of UV-irradiated tumor-bearing animals to low dose gamma radiation was capable of influencing the tumor susceptible state. This type of therapy, theoretically designed to selectively depress suppressor T cell function in vivo, appears to enhance the degree of tumor immunity by removing regulatory influences. We believe that these studies establish the importance of immunoregulatory mechanisms in host-UV tumor interactions.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.122.6.2458
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
1979
detail.hit.zdb_id:
1475085-5
Permalink