In:
Infection and Immunity, American Society for Microbiology, Vol. 22, No. 2 ( 1978-11), p. 411-417
Abstract:
Using a guinea pig model, we demonstrated that infections with pathogenic species of spotted fever group rickettsiae transiently and nonspecifically suppress established cellular immune responses as measured by in vitro lymphocyte transformation and in vivo delayed cutaneous hypersensitivity responses to unrelated, nonrickettsial antigens. The correlation of the duration of this immunosuppression with the virulence of the infecting rickettsial species suggests that this suppression is a pathological effect of the rickettsial infection. Although we did not specifically study the mechanism of this suppression, it is not associated with either lymphocytopenia or leukocytosis.
Type of Medium:
Online Resource
ISSN:
0019-9567
,
1098-5522
DOI:
10.1128/iai.22.2.411-417.1978
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1978
detail.hit.zdb_id:
1483247-1
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