In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 8, No. 4 ( 1975-10), p. 474-478
Abstract:
Equine abortion virus (EAV)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. These experiments demonstrate that 9-β- d -arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of ∼60. Ara-HxMP prevented hepatitis-associated deaths in hamsters, reduced the titer of EAV developing in hamsters, and inhibited the increase of serum glutamic pyruvic transaminase in EAV-infected hamsters.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1975
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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