In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 81, No. 1 ( 1976-01), p. 120-132
Abstract:
Conscious sheep with permanent indwelling cannulae in the lateral ventricles and the cisterna magna were Na depleted and then perfused for 9 h with an artificial CSF solution. There were 3 experimental groups: Group I (n = 5) received perfusion with artificial CSF containing Na 170 mEq./l, Group II (n=7) received perfusion with artificial CSF containing Na 145 mEq./l, Group III (n = 7) received no perfusion. In Group I the blood aldosterone level fell from 26.4 ± 7.4 to 8.6 ± 2.3 ng/100 ml by 9 h after perfusion. There was no significant change in plasma [Na] or [K] , blood angiotensin II or plasma renin concentration. Blood cortisol and corticosterone levels rose. There was also a fall in blood aldosterone in Group II but this was not significant until 4 h post-perfusion. Group III showed no significant change in blood aldosterone concentration. Multivariate statistical analysis showed that the fall in aldosterone levels during 170 mEq./l Na perfusion could not be accounted for by changes, either alone or together, of ACTH as evidenced by alteration in blood cortisol or corticosterone, or by change of plasma [Na], [K] or renin concentrations. This data supports the hypothesis of an additional factor which may be of CNS origin being involved in the control of aldosterone secretion.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0810120
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1976
detail.hit.zdb_id:
1485160-X
Permalink
