Electronic Resource
Springer
Acta neuropathologica
33 (1975), S. 185-190
ISSN:
1432-0533
Keywords:
Guinea pig
;
Lead
;
Encephalopathy
;
Blood-brain barrier
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Acute lead encephalopathy was induced in adult guinea pigs with daily oral doses of lead carbonate. Cerebral capillaries were examined by electron microscopy, and the blood-brain barrier (B-BB) evaluated with Evans blue and horseradish peroxidase. Brain lead levels were also determined during the developing encephalopathy. There was no cerebral capillary alteration or demonstrable B-BB dysfunction. Brain lead concentrations increased over the 5-day period. The encephalopathy in the absence of any vascular alteration suggests that lead can produce a primary toxic effect at the neuronal level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00688392
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