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Localization and Some Biological Properties of Pig Alpha-fetoprotein (1978)

KOVÁR̂Ů, F. ; POSPÍŜIL, M. ; TREBICHAVSKÝ, I. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 8 (1978), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: In studies of the cellular localization of AFP with the use of immunofluorescent, immunochemical and immunoautoradiographic techniques we concentrated in the course of prenatal ontogeny of pigs on the mesenchymal haemopoictic population of lymphatic and haemopoietic organs of these animal species. A marked AFP positivity was demonstrated already in haemopoietic cells of yolk sac, but also in other organs of embryonic and fetal haemopoiesis. In the course of intrauterine development the percentage of AFP-positive haemopoietic cells decreases and postnatally the AFP positivity of haemopoietic cells does not occur. The decrease in AFP-positivity of haemopoietic fetal cells is in correlation with the subsequent decrease in the intensity of extramedullary haemopoiesis. In the system in vitro the inhibitory effect of pig AFP on T and B cell mitogen-induced blast transformation of lymphocytes was demonstrated, similarly as on the mixed lymphocyte reaction. That effect of AFP is dependent on its presence in the first 24 hrs of stimulation and is not species specific. In fetal cell suspensions of lymphatic and haemopoietic organs of pigs their capacity for blastogenic transformation with anti-AFP serum was demonstrated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb03933.x

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Electrophoretic Behaviour of H and L Chains of Human Serum and Colostrum Gamma-globulin (1966)

REJNEK, J. ; KOSTKA, J. ; KOTÝNEK, O.

[s.l.] : Nature Publishing Group

Nature 209 (1966), S. 926-928

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] The L chain is the carrier of antigenic and allotypic determinants common to all types of immunoglobulins; its high degree of heterogeneity is apparent on starch-gel electrophoresis in formic acid and urea6 and especially in glycine and urea. This mode of electrophoretic separation allows ...