ISSN:
0173-0835
Keywords:
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Prolonged isoelectric focusing (IEF) of human saliva in narrow pH range polyacrylamide gels (pH 5-7) gave evidence for the existence of a new allele in the amylase1 (AMY1) system. It has tentatively been designated AMY15 and, inherited in an autosomal codominant way, as the variant phenotype AMY1 5-1, was observed in four individuals of a Yugoslavian family through three generations. The isoelectric point (pI) of the AMY15 gene product is intermediate to AMY1 1 and AMY1 2. The allele frequencies of AMY1 in 170 healthy, unrelated individuals from Hesse, Germany, were determined as follows: AMY11 = 0.909, AMY12 = 0.070, and AMY13 = 0.021. With a single exclusion chance of 8.0 % for non-fathers, AMY1 might become a useful genetic marker in cases of disputed paternity as well as for “gene mapping” the fine structure of chromosome 1 in man.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elps.1150010313
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