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  • 1
    ISSN: 1432-1076
    Keywords: Insulin dependent diabetes ; Remission ; Glucose ; Tolbutamide ; Arginine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The insulin secretory capacity was examined in diabetic children at the time of partial clinical remission during which their condition could be managed with low insulin therapy (〈0.5 U insulin/kg body weight) and no urinary glucose excretion. The extent of the residual beta cell function in 26 children was assessed either by an i.v. arginine test, a combined i.v. glucose-i.v. arginine test, a combined i.v. tolbutamide-i.v. arginine test, or a combined oral glucose-i.v. arginine test determining the C-peptide response by calculating the area under the curve above baseline levels. Two of the children were tested repeatedly. Under the above conditions i.v. glucose and i.v. tolbutamide did not release C-peptide in diabetic children. In contrast, C-peptide secretion during arginine infusion following i.v. glucose or i.v. tolbutamide was siginficantly enhanced compared to the C-peptide secretion observed during arginine infusion alone. The C-peptide response to oral glucose was sluggish with no effect on the following arginine infusion. The results indicate that during remission in juvenile onset diabetes i.v. glucose and i.v. tolbutamide without themselves being an appropriate signal for C-peptide release amplify the response to a subsequent arginine infusion under appropriate conditions.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 142 (1984), S. 260-265 
    ISSN: 1432-1076
    Keywords: Height prediction ; Height reduction ; Excessively tall girls ; High-dose oestrogen treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-one girls with familial tall stature were reevaluated at 18 years of age. Fourteen of them had been treated with high-dose oestrogens (I), while seven girls had not been treated (II). The untreated group is comparable but not a strict control group. Recordings on initiation of the study were: Chronologic age: 12.0±1.4 (I) versus 13.5±1.5 years (II; x), Bone age: (1) Greulich-Pyle: 11.8±1.4 (I) versus 13.1±1.1 years (II), (2) Tanner-Whitehouse II: 12.7±1.0 (I) versus 13.6±1.1 years (II). Mean height predictions according to (1) Bayley-Pinneau, (2) Roche-Wainer-Thissen and Tanner (3) with, and (4) without allowance for midparent height ranged from 179.4–184 (I) to 175.7–179.5 cm (II). In the treated group there was an average reduction of predicted height of between 2.3 and 6.5 cm, depending on which of the four methods was used. In the untreated group the average differences between calculated and observed mature height varied from 0.2–3.4 cm. The difference in the reduction of predicted height between the treated and untreated groups was significant (P〈0.05) only with the Bayley-Pinneau method and not with the others. In the treated group highly significant correlations were found between height reduction and the initial chronologic age, bone age and duration of therapy.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Diabetes mellitus type I ; Initial metabolic decompensation ; Duration of remission ; HbA1c
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 21 newly diagnosed children with type I diabetes mellitus initial hemoglobin A1c-concentrations, mean insulin requirements during the first 10 days of treatment to recompensate carbohydrate metabolism, duration of glucosuria after diagnosis and duration of remission were determined. Initial hemoglobin A1c-concentration and both mean insulin requirement during the first 10 days of treatment and duration of initial glucosuria showed a highly significant positive correlation. A highly significant, negative correlation was found between the duration of remission and both the mean insulin requirement during the first 10 days of treatment and the duration of initial glucosuria. Thus the present results together with previous findings suggest that the severity of initial metabolic decompensation in diabetes mellitus type I seems to determine at least in part the duration of remission.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 356 (1982), S. 299-302 
    ISSN: 1435-2451
    Keywords: Child ; Hyperinsulinism ; Pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei derβ-Zell-Hyperplasie des Pankreas im Kindesalter muß die Diagnose und operative Therapie wegen der neurologischen Schädigung durch die rezidivierenden Hypoglykämien so früh wie möglich erfolgen. Anhand von 2 Kindern mit einer Nesidioblastosis wird festgestellt, daß übereinstimmend mit der Literatur nur die subtotale Pankreatektomie zum Erfolg führt, da die endokrine Aktivität nach $${\raise0.5ex\hbox{$\scriptstyle 2$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle 3$}}$$ -Resektion zu hoch ist.
    Notes: Summary Two children withβ-cell nesidioblastosis are described. The importance of early diagnosis is stressed and the extent of the pancreatectomy with preservation of the spleen is pointed out. It is suggested that the first operation should be subtotal pancreatectomy because otherwise the endocrine activity of the pancreas is too high.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 505-505 
    ISSN: 1435-2451
    Keywords: Child ; Hyperinsulinism ; Kind ; Hyperinsulinismus ; Pankreas ; Pankreasresektion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei derβ-Zell-Hyperplasie des Pankreas im Kindesalter muß die Diagnostik und operative Therapie wegen der neurologischen Schädigung durch die rezidivierenden Hypoglykämien so früh wie möglich erfolgen. Anhand von 2 Kindern mit einer Nesidioblastosis wird festgestellt, daß übereinstimmend mit der Literatur nur die subtotale Pankreatektomie zum Erfolg führt, da die endokrine Aktivität nach 2/3-Resektion zu hoch ist.
    Notes: Summary Two children withβ-cell nesidioblastosis are described. The importance of early diagnosis is stressed and the extent of the pancreatectomy with preservation of the spleen is pointed out. It is suggested that the first operation should be subtotal pancreatectomy because otherwise the endocrine activity of the pancreas is too high.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
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