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  • 1
    Electronic Resource
    Electronic Resource
    Subpopulations of Human T Lymphocytes: Laboratory and Clinical Studies (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 56 (1981), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1981.tb01048.x
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  • 2
    Electronic Resource
    Electronic Resource
    Autologous Mixed Lymphocyte Reaction in Man (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 38 (1983), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The proliferative response of T lymphocyte cultured with autologous non-T lymphocyte is known as the autologous mixed lymphocyte reaction (AMLR). In AMLR. Both helper and suppressor functions are generated. In this investigation we have examined I cell proliferative responses in AMLR in 12 patients with bronchia asthma 10 patients with allergic rhinitis, and 10 patients with atopic dermatitis and compared that with simultaneously with bronchial asthma is significantly higher than that of health normals. However, AMRL response in patients with allergic rhinitis or atopic dermatitis is comparable to controls. Mechanisms for increased AMLR in patients with bronchial asthma are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1983.tb01594.x
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  • 3
    Electronic Resource
    Electronic Resource
    Voltage-gated K + channels in human T lymphocytes: a role in mitogenesis? (1984)
    [s.l.] : Nature Publishing Group
    Nature 307 (1984), S. 465-468 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Figure 1 shows outward potassium currents recorded from a human T lymphocyte in the whole cell conformation. Depolarizing voltage steps up to ?40 mV given from a holding potential of -80 mV produce very small leakage currents, representing an input resistance of greater than 20 GO for this cell. At ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/307465a0
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  • 4
    Electronic Resource
    Electronic Resource
    Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans (1981)
    Springer
    Journal of clinical immunology 1 (1981), S. 141-148 
    Details
    ISSN: 1573-2592
    Keywords: Natural killer cells ; antibody-dependent cytotoxicity ; aging ; lymphocyte subpopulations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) were examined in the peripheral blood lymphocytes and their major subpopulations from young and aging subjects. Monocyte-depleted unseparated lymphocyte-mediated NK activity (against cells of K-562) and ADCC (against IgG-coated chicken erythrocytes) were comparable between young and aging subjects. Similarly no significant difference was observed in T cell-mediated NK and ADCC and non-T cell-mediated ADCC between young and aging subjects. Non-T cell-mediated NK activity, however, was significantly (P〈0.025) greater in aging humans compared to that of young subjects. When the data were analyzed according to gender, T cell-mediated ADCC in aging males was significantly (P〈0.05) greater than that found in young males. No significant difference was observed between T-cell ADCC among young and aging females. T cell-mediated NK was comparable among young and aging males and young and aging females. Non-T cell-mediated NK as well as ADCC activity was significantly (P〈0.025 or 〈0.05) greater in aging males compared to that in young males. Both non-T-cell NK and ADCC were comparable among young and aging females. This study demonstrates an increase in NK and ADCC activity in aging subjects that is primarily shared by males and not by females. No correlation was observed between the proportion of Tγ cells and T-cell NK or ADCC activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00922755
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  • 5
    Electronic Resource
    Electronic Resource
    Human T-lymphocyte subset production of immune (γ) interferon (1981)
    Springer
    Journal of clinical immunology 1 (1981), S. 186-194 
    Details
    ISSN: 1573-2592
    Keywords: Human Tμ, Tγ, Tφ lymphocytes ; γ interferon ; macrophage-lymphocyte interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human Tμ, Tγ, and Tφ lymphocyte subpopulations have the capacity to respond to phytohemagglutinin (PHA)in vitro with proliferation and the production of a pH 2 and heat-labile γ interferon. This occurs both when the subsets are isolated by direct rosetting techniques or by negative selection. Macrophages enhance the production of the γ interferon by each lymphocyte subset and do not themselves produce γ interferon in response to products of PHA-activated lymphocyte subsets. Thus our studies indicate that subpopulations of T lymphocytes known to differ with regard to morphology, surface receptors, RNA content, response to corticosteroids and X-irradiation, and other functional capabilities do not differ with regard to their capacity to produce γ interferon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00922762
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  • 6
    Electronic Resource
    Electronic Resource
    Autologous mixed lymphocyte reaction in man. II. Histamine-induced suppression of the autologous mixed lymphocyte reaction by T-cell subsets defined with monoclonal antibodies (1981)
    Springer
    Journal of clinical immunology 1 (1981), S. 241-249 
    Details
    ISSN: 1573-2592
    Keywords: T-cell subsets ; histamine-induced suppressor function ; autologous mixed lymphocyte reaction ; monoclonal antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human peripheral blood mononuclear cells were separted into T and non-T cells by E-rosette formation. The influence of histamine (10−8−10−3 M) on the proliferative response of T cells in autologous and allogeneic mixed lymphocyte cultures (MLC) was studied. Pretreatment of responder T cells but not of stimulator non-T cells with histamine for 24 hr resulted in a markedly diminished proliferative response in both autologous and allogeneic MLC. A minimum of 4 hr of incubation of T cells with histamine was required to inhibit autologous MLC. Furthermore, T cells pretreated with histamine followed by mitomycin C treatment, when cocultured with fresh autologous T cells, suppressed their proliferative response in both autologous and allogeneic MLC. Analysis with OKT4 and OKT8 monoclonal antibodies revealed that histamine-induced suppressor T cells were contained in OKT 8 + -cell subset. Hitamine-treated OKT 4 + cells had no suppressive effect on the proliferative responses of autologous T cells. Supernatants of T cells cultured with histamine for 24 hr also suppressed both autologous and allogeneic MLC responses of fresh T cells, suggesting that the suppression could be mediated by a soluble suppressor factor(s). Experiments with H1 and H2 agonists and antagonists indicated that histamine-induced activation of suppressor T cells and the production of a soluble suppressor factor(s) were mediated through histamine type 2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915143
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  • 7
    Electronic Resource
    Electronic Resource
    Autologous mixed lymphocyte reaction in man. IV. Decreased autologous mixed lymphocyte culture response in patients with common variable immunodeficiency (1983)
    Springer
    Journal of clinical immunology 3 (1983), S. 78-83 
    Details
    ISSN: 1573-2592
    Keywords: Autologous mixed lymphocyte reaction ; primary immunodeficiency ; T-cell subsets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The autologous mixed lymphocyte reaction (AMLR) was studied in 18 patients with common variable immunodeficiency. The AMLR was decreased in 10 of 18 (55%) patients with common variable immunodeficiency compared to healthy controls. In allogeneic MLR, T cells from patients were found to be poor responders, and non-T cells poor stimulators, compared to allogeneic MLR between healthy normal controls. In allogeneic MLR, B cells (B cells + null cells) from patients were poor stimulators, whereas macrophages stimulated normally compared to controls. The deficient AMLR could be one of the mechanisms responsible for the increased risk of autoimmune phenomena in a subset of patients with primary immunodeficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00919142
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  • 8
    Electronic Resource
    Electronic Resource
    Lymphocyte transformation induced by autologous cells. XV. Xenoantigens are not required for the proliferative response observed in the autologous mixed lymphocyte reaction (1983)
    Springer
    Journal of clinical immunology 3 (1983), S. 100-102 
    Details
    ISSN: 1573-2592
    Keywords: Autologous mixed lymphocyte reaction ; sheep erythrocytes ; fetal calf serum ; xenoantigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The autologous mixed lymphocyte reaction is the proliferative response of T cells cultured with autologous non-T cells. This reaction has been described as being immunological in nature, i.e., possessing memory and specificity. The generation of T cells with regulatory and effector function has also been reported during the course of this reaction. More recently it has been reported that the proliferative response observed is due to the exposure of T cells to xenoantigens used in separating T and non-T cells. We have found that the presence of antigens such as sheep erythrocytes and fetal calf serum is not required for the induction of proliferation in T cells by autologous non-T cells, although exposure to such antigens may augment [3H]thymidine incorporation. In certain individuals who are sensitized to these xenogeneic antigens, the proliferative response of their lymphocytes in the autologous mixed lymphocyte reaction is very greatly enhanced if exposed to xenoantigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00919145
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  • 9
    Electronic Resource
    Electronic Resource
    Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus (1984)
    Springer
    Journal of clinical immunology 4 (1984), S. 424-428 
    Details
    ISSN: 1573-2592
    Keywords: Insulin-dependent diabetes mellitus ; autologous mixed lymphocyte response ; interleukin-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The autologous mixed lymphocyte response (AMLR) and the allogeneic mixed lymphocyte response were deficient in a subset of patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Using a single set of HLA-identical twins, the cellular and molecular basis of deficient AMLR was investigated and appears to be due to a defect in both responder T cells and stimulator non-T cells. Interleukin-2 production was diminished in the patient but not in the healthy twin. Thein vitro addition of purified interleukin-2 enhanced the depressed AMLR in the diseased twin. This suggests that the deficient AMLR in IDDM may be in part due to a deficiency in the production of interleukin-2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00916571
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  • 10
    Electronic Resource
    Electronic Resource
    Book reviews (1982)
    Springer
    Journal of clinical immunology 2 (1982), S. 246-248 
    Details
    ISSN: 1573-2592
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915229
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