In:
Microbiology and Immunology, Wiley, Vol. 26, No. 7 ( 1982-07), p. 575-583
Abstract:
The target antigen for Epstein‐Barr virus (EBV)‐specific cytotoxic T cells (Tc) was expressed on BJAB cells exposed to the B95‐8 strain of EBV for at least one hour. Ultraviolet‐light (UV)‐irradiated noninfectious B95‐8 virus also induced the target antigen on BJAB cells. Cold target competition tests suggested that the target antigen expressed on EBV‐infected BJAB cells was distinct from the lymphocyte‐detected membrane antigen (LYDMA) which was also recognized by the EBV‐specific Tc and expressed on autologous EBV‐transformed lymphoblastoid cell line (LCL) cells. Neither of these target antigens for EBV‐specific Tc was detected on the surface of EBV‐genome positive BJAB cells which had been kept in a long‐term culture after EBV‐infection. Thus, the virion antigen, especially the EBV‐membrane antigen (MA), is a possible candidate for the target antigen expressed on EBV‐infected BJAB cells. Lysis of EBV‐infected BJAB cells was inhibited by target cell treatment with anti‐ β 2 microglobulin (anti‐ β 2M) antibody and induction of the effector Tc was dependent on the donor individual. These resalts suggested the possibility that the Tc recognizing EBV‐infected BJAB cells are restricted by the major histocompatibility complex (MHC).
Type of Medium:
Online Resource
ISSN:
0385-5600
,
1348-0421
DOI:
10.1111/mim.1982.26.issue-7
DOI:
10.1111/mim.1982.26.7.575
Language:
English
Publisher:
Wiley
Publication Date:
1982
detail.hit.zdb_id:
2102145-4
SSG:
12
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