In:
FEBS Letters, Wiley, Vol. 176, No. 2 ( 1984-10-29), p. 381-384
Abstract:
The effects ofmalonyl CoA on carnitine palmityltransferase I (CPT‐I), fatty acid‐supported state 3 respiration, and carnitine reversal of palmityl CoA inhibition of state 3 respiration and of the adenine nucleotide translocator, were studied in isolated rat heart mitochondria. Malonyl CoA was a potent competitive inhibitor of CPT‐I with an I 50 of 0.8 μM. Fasting did not affect CPT‐I activity or the I 50 value of malonyl CoA. Malonyl CoA inhibited fatty acid‐supported respiration and prevented carnitine from reversing the inhibition of the adenine nucleotide translocator by palmityl CoA. These findings suggest that malonyl CoA may affect fatty acid oxidation in the heart.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(84)81201-6
Language:
English
Publisher:
Wiley
Publication Date:
1984
detail.hit.zdb_id:
1460391-3
SSG:
12
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