In:
The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 08, No. 01n02 ( 1980-01), p. 96-103
Abstract:
The effects of the Chinese herb Shan-dou-gen, Euchestra formosana, on metabolic, respiratory and vasomotor activities as well as body temperature were assessed in conscious rats at various ambient temperatures. Systemic administration of Shan-dou-gen produced a dose-dependent hypothermia in rats at room temperature (22°C) and below. The hypothermia in response to Shan-dou-gen was brought about by both cutaneous vasodilatation and decreased metabolic heat production. There were no changes in respiratory evaporative heat loss. However, in the heat (30°C), administration of Shan-dou-gen produced no changes in rectal temperature or other thermoregulatory variables. Furthermore, the hyppothermia induced by Shan-dou-gen was greatly antagonized by pretreatment of animals with 5,6-dihydroxytryptamine (predominantly a depletor of central serotonin nerve fiber), but not with 6-hydroxydopamine (a relative depletor of central catecholamine nerve fiber). It appears that the hypothermic effects of Shan-gou-gen may be mediated through serotonin release within the brain.
Type of Medium:
Online Resource
ISSN:
0192-415X
,
1793-6853
DOI:
10.1142/S0192415X80000086
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
1980
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