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  • Springer  (2)
  • 1980-1984  (2)
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  • Springer  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Cytosol estrogen and progesterone receptor levels measured in normal and pathological tissue of endometrium, endocervical mucosa and cervical vaginal portion (1983)
    Springer
    Archives of gynecology and obstetrics 233 (1983), S. 109-119 
    Details
    ISSN: 1432-0711
    Keywords: Steroid receptors ; Endocervix ; Vaginal portion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to compare cytosol estrogen (ER) and progesterone (PgR) receptor levels measured in normal and pathological tissue specimens (n = 395) of endometrium (ED), endocervical mucosa (EM) and cervical vaginal portion (VP) from 108 patients (age 27–79). The highest ER levels were found in ED which decreased to 25% in VP. The PgR decline was more pronounced in VP since the majority of samples were PgR-negative. In addition pathological tissue from ED exhibited marked differences in steroid receptor levels: The highest ER and PgR concentrations were detected in the proliferative phase, whereas the secretory phase exhibited significantly reduced ER and PgR levels. The lowest ER and PgR amounts were measured in atrophic and quiescent tissues; in proliferative tissue ER and PgR levels were comparable to hyperplastic tissue. Cervical ER and PgR concentrations were significantly lower as compared with ED (25–30%), and no cyclic variations were detectable. Also ER and PgR levels were different between EM and VP. 96% of ER were positive in the cervix, whereas 73% were PgR-negative in VP. Furthermore an inverse correlation between ER and progesterone was found in ED and a positive correlation between estradiol and PgR. These results suggest that the cytosol ER and PgR levels vary markedly in the uterine corpus and may explain in part the different response to endocrine therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114787
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cyclic AMP-dependent protein kinases and cAMP-binding proteins in human mammary tumor MCF-7 cells (1984)
    Springer
    Archives of gynecology and obstetrics 234 (1984), S. 173-179 
    Details
    ISSN: 1432-0711
    Keywords: MCF-7 cells ; Protein kinases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two isoenzymes of cAMP-dependent protein kinases were found in MCF-7 cytosol. The regulatory (cAMP-binding) subunit of protein kinase I (predominant form) has an apparent molecular weight (MW) of 49,000 and the two forms of regulatory subunits of protein kinase II have MWs of 52,000 and 54,000. Substantial amounts of the 49,000 protein cochromatographed on DEAE cellulose with protein kinase II. The quantities of protein kinase holoenzyme activity are strongly influenced by extraction procedures: the use of EDTA and of the protease inhibitor benzamidine can lead to extensive dissociation. On the other hand, high yields of cAMP-dependent protein kinase holoenzyme activity were consistently obtained with 150 mM KCl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570753
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    Paper (German National Licenses)
    Fulltext
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