In:
Kidney and Blood Pressure Research, S. Karger AG, Vol. 6, No. 6 ( 1983), p. 295-299
Abstract:
The effects of a natriuretic factor contained in extracts of the atrial myocardium on an isolated renal Na 〈 sup 〉 + 〈 /sup 〉 , K+-ATPase enzyme system were evaluated. Ultrafiltrates (molecular weight 〈 30,000) of boiled extract of rat atria and ventricles were prepared. Infusion of 100 µl of the atrial ultrafiltrate into bioassay rats resulted in a prompt, short-lived natriuresis and diuresis. However, addition of 100 µl of the atrial ultrafiltrate to 900 µl of a suspension containing Na 〈 sup 〉 + 〈 /sup 〉 , K 〈 sup 〉 + 〈 /sup 〉 -ATPase had no significant effect on enzymatic activity. Similarly, ultrafiltrates of ventricular extract also had no significant effect on Na 〈 sup 〉 + 〈 /sup 〉 , K 〈 sup 〉 + 〈 /sup 〉 -ATPase activity. These results indicate that the atrial natriuretic factor does not alter renal tubular sodium reabsorption by directly inhibiting the Na 〈 sup 〉 + 〈 /sup 〉 , K 〈 sup 〉 + 〈 /sup 〉 -ATPase enzyme system.
Type of Medium:
Online Resource
ISSN:
1420-4096
,
1423-0143
Language:
English
Publisher:
S. Karger AG
Publication Date:
1983
detail.hit.zdb_id:
1482922-8
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