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  • 1
    Electronic Resource
    Electronic Resource
    On the Role of Calcium Ions in the Regulation of Glycogenolysis in Mouse Brain Cortical Slices (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Using mouse brain cortical slices, we investigated the relative roles of cyclic AMP and of calcium ions as the intracellular messengers for the activation of glycogen phosphorylase (EC 2.4.1.1; α-1,4-glucan:orthophosphate glucosyltransferase) induced by noradrenaline and by depolarization. Activation of phosphorylase by 100 μM noradrenaline is mediated by β-adrenergic receptors and does not require the copresence of adenosine. The role of the concomitant small increase in cyclic AMP is questioned. Short-term treatment with EGTA or LaCl3 abolishes the noradrenaline activation of phosphorylase, pointing to a critical role of extracellular calcium. Depolarization by 25 mM K+ or 100 μM veratridine produces a rapid and large (fourfold) activation of phosphorylase. Only veratridine increases the cyclic AMP levels; exogenous adenosine deaminase essentially blocks this cyclic AMP accumulation but not the phosphorylase activation. A halfmaximal activation of phosphorylase occurs at about 12 mM K+. Addition of EGTA or LaCl3, reduces the effect of both depolarizations to a slight and transient activation of phosphorylase. These results indicate that activation of glycogen phosphorylase by K+ or veratridine occurs by a cyclic AMP-independent and calcium-dependent mechanism. The calcium dependency of brain phosphorylase kinase renders this kinase the prime target enzyme for regulation of glycogenolysis by calcium ions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb07903.x
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  • 2
    Electronic Resource
    Electronic Resource
    Inactivation-cross-section of mammalian tissue culture cells irradiated with heavy ions (1981)
    Springer
    Radiation and environmental biophysics 19 (1981), S. 305-305 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324111
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  • 3
    Electronic Resource
    Electronic Resource
    Chromosome analysis in patients with sarcoidosis (1980)
    Springer
    Archives of dermatological research 268 (1980), S. 9-13 
    Details
    ISSN: 1432-069X
    Keywords: Chromosome-breaks ; Chromosome-gaps ; Chromosomes ; Glucocorticoide ; Hypomodal cells ; Sarcoidosis ; Chromosomenspalt ; Chromosomenbruch ; Chromosomen ; Glucocorticoide ; hypomodale Zellen ; Scaroidosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Chromosom-Analyse der Lymphocyten des peripheren Blutes von 20 Patienten mit Sarcoidosis und 10 gesunden Kontrollpersonen zeigte eine signifikant größere Anzahl von hypomodalen Zellen bei den Patienten. Zwei Patienten, die mit Glucocorticoiden behandelt wurden, hatten viele chromosomale Mißbildungen.
    Notes: Summary Chromosome analysis of lymphocytes from the peripheral blood of 20 patients with sarcoidosis and 10 healthy controls showed a significantly greater number of hypomodal cells among the patients. Two patients receiving systemic treatment with glucocorticoids had many chromosomal aberrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403881
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  • 4
    Electronic Resource
    Electronic Resource
    Localization of radioactivity in rat organs after oral administration of tritiated 8-methoxypsoralen in therapeutic doses (1982)
    Springer
    Archives of dermatological research 273 (1982), S. 71-84 
    Details
    ISSN: 1432-069X
    Keywords: 3H-8-MOP ; DNA-RNA protein activity ; 3H-8-MOP time activity curves ; Rat organs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tritiated 8-methoxypsoralen was given perorally to rats in amounts corresponding to therapeutic human doses. The rats were exposed to UVA light or kept in darkness. None of the fractions (apart from 3H2O from the lens) examined changed their level of radioactivity under the influence of UVA light. Time-radioactivity curves were recorded for the skin, lens, residual eye, and the liver. Four fractions were measured: 3H2O, soluble pool, DNA-RNA, and protein. Tritiated water appeared already 1 h after ingestion, and attained maximum value 9–24 h after ingestion, indicating the efficiency with which the liver degrades 8-MOP. 3H-8-MOP and metabolites could be detected in the soluble pool in maximum amounts 2–3 h after the administration. Pretreatment with trypsin increased the concentration of 3H-8-MOP and metabolites; the origin of this extra radioactivity was the protein fraction. The 3H-8-MOP binding to DNA or RNA was studied by pretreatments of the homogenates with DNase or RNase followed by measurement of radioactivity in the TCA extracts. This indicated that no measurable amount of 3H-8-MOP had been bound to DNA or RNA. We conclude that 8-MOP administered to rats in amounts corresponding to human therapeutic doses does not bind to DNA or RNA in measurable amounts either after UV-light or in darkness. The experiments have shown proteins to be the main binding site in rat organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509029
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  • 5
    Electronic Resource
    Electronic Resource
    Toxic Effects of 8-Methoxypsoralen on Lymphocyte Devision (1977)
    Springer
    Archives of dermatological research 260 (1977), S. 87-92 
    Details
    ISSN: 1432-069X
    Keywords: Lymphocyte growth ; Psoralen ; Cell culture ; UVA action ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gezüchtete humane Leukocyten sind für die Untersuchung der Toxicität und der Phototoxicität des 8-Methoxy-Psoralen (8-MOP) verwendet worden. Man hat festgestellt, daß 8-MOP in einer Konzentration von mehr als 10−10 M die Zellteilung hemmt. Bei 8-MOP und black light (UVA) fängt die Hemmung bei 10−14 M an. Bei Patienten, die wegen Psoriasis mit 8-MOP behandelt werden, zeigen sich Konzentrationen von 10−6-10−7 M. Die mit der hier angewendeten Technik festgestellten Hemmung der Zellteilung beträgt bei dieser Konzentration für 8-MOP allein 40% und für 8-MOP + UVA 70%. Diese Ergebnisse sind mit dem Befund an Mikronuclei und Chromosomabnormalitäten in sich teilenden Zellen in Zusammenhang zu sehen.
    Notes: Summary Cultured human leucocytes have been used to examine the toxicity and phototoxicity of 8-methoxy psoralen (8-MOP). It has been shown that 8-MOP depresses cell turnover at concentrations of 10−10 M or above. In black light (UVA), 8-MOP inhibition begins at concentrations of 10−14 M. Patients treated for psoriasis with 8-MOP show concentrations of 10−6-10−7 M. The inhibition of cell turnover observed with the present technique is at this concentration 40% for 8-MOP alone and 70% for 8-MOP and black light. These results can be related to the micronuclei and chromosome abnormalities seen in dividing cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561113
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  • 6
    Electronic Resource
    Electronic Resource
    Acute effect of 8-methoxypsoralen and ultraviolet light on sister chromatid exchange (1978)
    Springer
    Archives of dermatological research 263 (1978), S. 37-46 
    Details
    ISSN: 1432-069X
    Keywords: Sister chromatid exchange ; 8-MOP ; ultraviolet light ; Schwester-chromatiden-Austausch ; 8-MOP, langwelliges UV-Licht
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die unmittelbare Wirkung von 8-Methoxypsoralen (8-MOP) sowie von 8-MOP+langwelligem UV-Licht (UVA) auf Schwesterchromatiden-Austausch (SCE) wurde in einem in vitro-Experiment untersucht. Der SCE nach 8-MOP allein war signifikant erhöht, aber die Wirkung war wesentlich größer (50%) nach der Behandlung mit 8-MOP+UVA. Dazu wurden nach der Behandlung mit 8-MOP-Mitosen mit «gestreifter» Färbung der Chromosomen beobachtet. Die Veränderungen sind dosisabhängig und bilden möglicherweise die Ursache für die nach PUVA-Behandlung verminderte Zellteilung in Psoriasisflecken.
    Notes: Summary The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP+long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP+UVA. In addition, mitoses with banded staining of the chromosomes were seen after 8-MOP and UVA. These changes were dose dependent, and they might be responsible for the reduced cell turnover in psoriasis plaque after PUVA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446852
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  • 7
    Electronic Resource
    Electronic Resource
    Ein neuartiges Bauprinzip in den Kristallstrukturen der Bleiniobate vom Pyrochlor-Typ (1980)
    Springer
    Naturwissenschaften 67 (1980), S. 141-142 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01073617
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  • 8
    Electronic Resource
    Electronic Resource
    Implementation of an in vitro fertilization program (1984)
    Springer
    Journal of assisted reproduction and genetics 1 (1984), S. 72-75 
    Details
    ISSN: 1573-7330
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The establishment of an in vitro fertilization program is described. Organization of the physical laboratory, media formulation, and preliminary mouse embryo culture are discussed. Parameters of patient eligibility, ovarian stimulation, and laporoscopy are also defined. At the conclusion of Phase I, 17 patients were induced; 10 went to laparoscopy, and at least one four-cell embryo was returned to 7, resulting in one continuing pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01129624
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