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  • 1
    Electronic Resource
    Electronic Resource
    Zur quantitativen darstellung (säulenchromatographische Trennung) saurer mucopolysaccharide im Urin bei der progressiven Sklerodermie (1977)
    Springer
    Archives of dermatological research 259 (1977), S. 11-19 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An einem umfassenden Krankengut der progressiven Sklerodermie (n = 20) wurden gegenüber Kontrollen Hexosaminbestimmung und anschließende säulenchromatographische Auftrennungen durchgeführt. Verwendung fanden hierbei moderne Testmethoden zur Darstellung der Parameter des Mucopolysaccharidstoffwechsels (Hexosaminbestimmung nach Südhoff u. Petrovic sowie das säulenchromatographische Auftrennungsverfahren nach Greiling u. Stuhlsatz. Die mit der Hexosaminbestimmung dargestellte vermehrte Ausscheidung in Korrelation zu erheblichen Sulfateinbauraten in die Haut wurde im Sinne einer Acceleration des Proteoglykanstoffwechsels in der Haut gedeutet. Die entsprechenden Ausscheidungsprodukte konnten nicht als typische Vertreter der in der Haut befindlichen Proteoglykanbestandteile identifiziert werden. Zur Darstellung kam wiederum ein erhöhter Anteil von Glykopeptiden sowie ein erhöhter Anteil von Chondroitin oder besonders niedrig sulfatierter Chondroitinsulphat-Bruchstücke. Damit konnte aufgezeigt werden, daß die Hexosaminbestimmung im Urin in ihrer Aussagekraft und Rückschlüssen auf den Mucopolysaccharidstoffwechsel limitiert ist.
    Notes: Summary After filtration the urine was concentrated to about 1/10 of the original volume. The urine was centrifuged for 15 min at 5000 rev/min. The supernatant was chromatographed on Bio-Gel P-2—with a 10% aqueous solution of ethanol. Then the glycosaminoglycan fraction was separated into seven further fractions by chromatography on Dowex 1 × 2 and elution with increasing concentration of sodium chlorid. The desalted fractions were analysed. From the analytical data presented no definite correlation between excretion of glycosaminoglycans in urine und progressive scleroderma can be observed. These results were discussed with further data presented by Hexosamine determination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562733
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  • 2
    Electronic Resource
    Electronic Resource
    Superoxide dismutase in human semen (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 63-65 
    Details
    ISSN: 1432-1440
    Keywords: Superoxide dismutase ; Lipid peroxidation ; Seminal plasma ; Superoxide radicals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amounts of Copper/zinc containing superoxide dismutase have been found in human seminal plasma. Superoxide dismutase inhibits the lipid peroxidation in the xanthine oxidase system. In seminal plasma of spermatozoa with a good motility the superoxide dismutase activity is higher than in those with a low motility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484441
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  • 3
    Electronic Resource
    Electronic Resource
    The ratio of glycosaminoglycans to collagen in the skin in malignant melanoma (1981)
    Springer
    Archives of dermatological research 272 (1981), S. 67-71 
    Details
    ISSN: 1432-069X
    Keywords: Glycosaminoglycans ; Collagen ; Malignantmelanoma ; Hexosamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The interaction between glycosaminoglycans and collagen was determined in 24 subjects with malignant melanomas. The analysis indicates that the ratio of hexosamine to collagen was higher in the center of the tumor than in the outer areas. Our findings could result from dysregulation of the biosynthesis of glycosaminoglycanes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510395
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  • 4
    Electronic Resource
    Electronic Resource
    Fettsäureverteilung der Haarlipide bei der Psoriasis vulgaris (1979)
    Springer
    Archives of dermatological research 264 (1979), S. 339-343 
    Details
    ISSN: 1432-069X
    Keywords: Fatty acids ; Psoriasis vulgaris ; Hair lipids ; Fettsäuren ; Psoriasis vulgaris ; Haarlipide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der gas-chromatographischen Untersuchung der Fettsäureverteilung ds Haarfettes und der gemeinsam analysierten Kopfhaut- und Haarlipide bei einem Kollektiv von Patienten mit Psoriasis vulgaris wurden gegenüber einem Kontrollkollektiv von Hautgesunden eine signifikante Erhöhung der Laurinsäure festgestellt.
    Notes: Summary The composition of fatty acids of hair lipids and the sum of hair and scalp lipids from subjects with Psoriasis vulgaris and a control group was determined by gas liquid chromatography. The analyses indicates that the percentage compositions of lauric acid was distinctly higher by Psoriasis vulgaris.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412662
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  • 5
    Electronic Resource
    Electronic Resource
    HLA-linked complement polymorphisms (C2, BF) in psoriasis (1983)
    Springer
    Archives of dermatological research 275 (1983), S. 301-304 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; Complement ; C2 ; Factor B ; Polymorphism ; HLA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Starting from the known association between psoriasis and several HLA antigens and from the fact that the HLA chromosomal region contains the structural genes for at least three complement components, the authors have looked for an association between psoriasis and allotypes of C2 and BF. C2 and BF polymorphism were examined in 230 psoriatic patients. Two rare complement genes were found to be significantly increased when compared with controls: the frequency of the C2 *2 gene was 0.061 among patients and 0.035 among controls (P〈0.05); for BF *SO7, the frequencies were 0.0304 in patients and 0.0092 in controls (P〈0.0005). The BF *F gene frequency, however, was significantly decreased among patients: 0.1196 vs. 0.1743 (P〈0.01). The relative risks were 1.79 for the C22, 3.44 for the BF SO7, and 0.6 for the BFF gene product. From previous studies, it is known that these three complement alleles (C2 *2, BF* SO7, BF *F) are in linkage disequilibrium with HLA alleles that have also been found increased or decreased, respectively, in psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417201
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  • 6
    Electronic Resource
    Electronic Resource
    Der Tryptophan-Stoffwechsel bei der progressiven Sklerodermie (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 881-887 
    Details
    ISSN: 1432-1440
    Keywords: Tryptophan load ; Tryptophan metabolism ; In controls and progressive scleroderma ; DL-Tryptophan ; Tryptophan-Metabolismus ; Kontrollen-progressive Sklerodermic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An einem Krankengut der progressiven Sklerodermie (n=11) gegenüber Kontrollen (n=10) wurden im 24 h-Urin vor, unter und nach der Belastung mit 5 g DL-Tryptophan 7 Metaboliten des Tryptophanabbaues (Kynurenin, 3-Hydroxyanthranilsäure, Xanthurensäure, 5-Hydroxyindolessigsäure, Indol-3-Essigsäure, N-Methylnicotinamid, Tryptamin) quantitativ bestimmt. Die 24 h-Ausscheidungen von 5-Hydroxyindolessigsäure und Indol-3-Essigsäure waren gegenüber dem Kontrollkollektiv signifikant erhöht. Ein Rückgang der Ausscheidung von 5-Hydroxyindolessigsäure nach Belastung bei Kontrollen deutet die Möglichkeit einer autonomen Regulation des Serotoninstoffwechsels sowie eine Störung der Regulation bei Sklerodermiepatienten an. Ein Versuch, unsere Ergebnisse denen bisher dem Schrifttum vorliegenden Untersuchungsbefunden gegenüberzustellen, ist aus methodentechnischen Gründen nicht durchführbar gewesen.
    Notes: Summary This presentation describes effects of oral tryptophan loading (5.0 g DL) on tryptophan metabolism in healthy subjects (n=10) and persons with progressive scleroderma. N1-methylnicotinamide (N1MN), 3-hydroxyanthranilic acid (3 HAA), kynurine (KN), tryptamin (TA), xantheurenic acid (XA) were determinated. Alterations of tryptophan metabolism were evaluated by 24 h urinary excretions of the following metabolites: 5-hydroxy indolacetic acid (5 HAA) and indole-3-acetic acid (IAA). The pathological pathways were discussed, especially the way and influence of serotonine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483590
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