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  • 1980-1984  (2)
  • 1975-1979  (5)
  • 1965-1969  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    NUCLEAR-CYTOSOL INTERACTIONS THAT MODULATE RNA SYNTHESIS AND TRANSCRIPT SIZE OF MOUSE BRAIN NUCLEI (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract– The addition of a dialyzed cytosol preparation from various types of mouse tissue, guinea-pig brain, and neuroblastoma cells resulted in an increased incorporation of [3H]GTP into RNA by mouse brain nuclei. In addition to a stimulation of the incorporation of [3H]GTP into RNA. the presence of these cytosol preparations also caused a significant increase in nuclear RNA transcript size. Although all cell cytosols appeared to influence nuclear RNA metabolism to some degree, dialyzed mouse serum had little stimulatory effect on brain nuclear RNA synthesis and failed to cause an increase in RNA product size. The polyanion, heparin, was found to be highly stimulatory to brain nuclear RNA synthesis although the size of the resulting RNA products was not significantly altered. RNA synthesis by neuronal and glial nuclei, isolated from adult brain tissue, showed a differential response to the presence of brain cytosol preparations. In the absence of cytosol, RNA synthesis by neuronal nuclei was more active than that measured in glial nuclei, and when the RNA products were analyzed by sucrose gradient centrifugation, those of glial nuclei were considerably larger than those isolated from neuronal nuclei. The addition of cytosol caused a significant increase in RNA transcript size with neuronal nuclei of adult brain tissue while little, if any, change in the size of the RNA products was measured with nuclei isolated from glial cells. Although an overall increase in product size could be measured in response to the addition of dialyzed cytosol with neuronal nuclei of 2,10, 20-day old and adult (over 60 days of age) brain tissue, a greater response was measured with nuclei prepared from the brains of more mature animals where the proportion of larger RNA products (〉10S) was greatly increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb02617.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    AMINOACYL-RNA SYNTHETASE AND TRANSFER RNA BINDING ACTIVITY DURING EARLY MAMMALIAN BRAIN DEVELOPMENT (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Aminoacyl-RNA synthetase activity in mouse brain tissue was measured during the first few days after birth. Although the rate of protein synthesis rapidly diminished during this period, the activity of these specific enzymes was not reduced. In contrast, the binding of tyrosine and arginine was actually greater when the older enzyme preparations were employed. The ability of tRNA to bind amino acids during this critical stage of development was tested. Preparations of tRNA, isolated from 2-, 7-, 11- and 13-day-old, and adult brain tissue were employed with both young and old enzymes. No significant loss in binding activity was measured with these tRNA preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb05957.x
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  • 3
    Electronic Resource
    Electronic Resource
    THE EFFECTS OF PHENYLALANINE ON AMINO ACID METABOLISM AND PROTEIN SYNTHESIS IN BRAIN CELLS IN VITRO (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 26 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Incubation of brain cell suspensions with 14 mM-phenylalanine resulted in rapid alterations of amino acid metabolism and protein synthesis. Both thc rate of uptake and the final intracellular concentration of several radioactively-labelled amino acids were decreased by high concentrations oi phenylalanine. By prelabelling cells with radioactive amino acids, phenylalanine was also shown to effect a rapid loss of the labelled amino acids from brain cells. Amino acid analysis after the incubation of the cells with phenylalanine indicated that several amino acids were decreased in their intracellular concentrations with effects similar to those measured with radioisotopic experiments (large neutral 〉 small and large basic 〉 small neutral 〉 acidic amino acids). Although amino acid uptake and efflux were altered by the presence of 14 mwphenylalanine, little or no alteration was detected in the resulting specific activity of the intracellular amino acids. High levels of phenylalanine did not significantly altcr cellular catabolism of either alanine, lysine, leucine or isoleucine. As determined by the isolation of labcllcd aminoacyl-tRNA from cells incubated with and without phenylalanine, there was little or no alteration in the level of this precursor for radioactive alanine and lysine. There was, however, a detectable decrease in thc labelling of aminoacyl-tRNA for leucine and isoleucine. Only aftcr correcting for the changes of the specific activity of the precursors and thcir availability to translational events, could the effects of phenylalanine on protein synthesis be established. An inhibition of the incorporation into protein for each amino acid was approximately 20%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb06993.x
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  • 4
    Electronic Resource
    Electronic Resource
    CELL-FREE PROTEIN SYNTHESIS BY MOUSE BRAIN DURING EARLY DEVELOPMENT (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Cell-free homogenates were employed to study the nature of the mechanism that is responsible for the rapid decrement in protein synthesis during early neural development. There was a progressive loss of polypeptide synthesis in post-mitochondrial fractions that were isolated from increasingly older tissue. By the time the animals were approximately 17 days old, the rate of amino acid incorporation had decreased to the rate that was measured in adult brain preparations. This decrement in synthetic activity was similar to that previously measured in developing intact brain cells. The loss in protein synthesis was demonstrated to be independent of cellular membrane permeability and under the influence of intracellular control mechanisms. Although the nature of the control mechanism is still not clear, a lack of template RNA to direct protein synthesis was not the limiting factor in the decreased synthesis of the older brain preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb06836.x
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  • 5
    Electronic Resource
    Electronic Resource
    NUCLEAR-CYTOSOL INTERACTIONS THAT FACILITATE RELEASE OF RNA FROM MOUSE BRAIN NUCLEI (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Mouse brain nuclei were incubated in vitro under conditions that primarily lead to the synthesis of radioactive polydisperse and messengerlike nuclear RNA. After incubation the effects of Mg2 concentrations, nucleoside triphosphate levels and brain cytosol were examined with regard to their ability to influence the release of RNA from brain nuclei. The presence of 8 mM-MgCl2 and a total of 0.3 mM-nuclcoside triphosphates during the labelling procedure allowed only a minimal amount of RNA to be released. However, when the MgCl2 was decreased to 2 mM and the nucleoside triphosphates were increased to 1 mM, a stimulation of RNA release was observed. The addition of unfractionated brain cytosol under these conditions resulted in an inhibition of RNA release.G-100 Sephadex filtration removed detectable RNase activity from the cytosol preparations and allowed the identification of fractions that were able to facilitate nuclear RNA release by 3-fold. The fractions that stimulated release did not have detectable levels of RNase, protease or DNA-dependenl RNA polymerase. Under conditions that provided maximum nuclear RNA release by both labelled mouse brain and neuroblastoma nuclei, no release of DNA could be measured. The cytosol fractions that facilitated RNA release did not have a high affinity for nuclear RNA or an ability to stimulate nuclear RNA synthesis. However, other components in the cytosol were shown to stimulate RNA metabolism in isolated mouse brain nuclei and to have a relatively high binding affinity to nuclear RNA. Further purification of the RNA release components in the brain cytosol by DEAF. Sephadex chromatography allowed an increase in specific activity of at least 40-fold. The thermal lability, effective filtration size, and solubility in phenol suggested that the cytosol factors that facilitiated nuclear RNA release were associated with cellular proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb12399.x
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  • 6
    Electronic Resource
    Electronic Resource
    THE EFFECTS OF MATURATION ON IN VITRO RNA SYNTHESIS BY MOUSE BRAIN CELLS (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 14 (1967), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1967.tb09518.x
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  • 7
    Electronic Resource
    Electronic Resource
    RNA METABOLISM IN ISOLATED MOUSE BRAIN NUCLEI DURING EARLY POSTNATAL DEVELOPMENT (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 24 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —RNA metabolism in isolated brain nuclei has been shown to be dramatically altered during early postnatal brain development. The present study involved an examination of the RNA products synthesized by nuclei at various stages of postnatal neural maturation. In all cases, the majority of the RNA appeared to be heterodisperse, non-ribosomal and non-tRNA in nature. In comparison to the RNA isolated from nuclei of neonatal tissue, the RNA from nuclei of 12-day and 30-day-old mouse brain was found to be of smaller molecular weight. Despite the heterodisperse nature of these RNA molecules, the addition of α-amanitin did not completely inhibit nuclear synthesis.An investigation of RNA synthesis in isolated neuronal and glial cell nuclei revealed that nucleic acid metabolism in these respective cell populations had different and distinct developmental patterns. Preparations enriched with glial cell nuclei were found to be most active at birth and then decreased in activity (3–4-fold) during neural maturation. On the other hand, the rate of RNA synthesis in fractions enriched in neuronal cell nuclei was observed to increase dramatically in activity (4–5-fold) until 14 days of age. From 14 days of age until adulthood, RNA synthetic activity remained essentially the same.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb03660.x
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  • 8
    Electronic Resource
    Electronic Resource
    Sedimentation in Large Lakes (1984)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Earth and Planetary Sciences 12 (1984), S. 179-204 
    Details
    ISSN: 0084-6597
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ea.12.050184.001143
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  • 9
    Electronic Resource
    Electronic Resource
    Contrasting modes of photosynthetic enzyme regulation in oxygenic and anoxygenic prokaryotes (1984)
    Springer
    Archives of microbiology 139 (1984), S. 124-129 
    Details
    ISSN: 1432-072X
    Keywords: Photosynthesis ; Regulation ; Thioredoxin ; Cyanobacterium ; Chromatium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Enzymes that are regulated by the ferredoxin/thioredoxin system in chloroplasts — fructose-1,6-bisphosphatase (FBPase), sedoheptulose-1,7-bisphosphatase purified from two different types of photosynthetic prokaryotes (cyanobacteria, purple sulfur bacteria) and tested for a response to thioredoxins. Each of the enzymes from the cyanobacterium Nostoc muscorum, an oxygenic organism known to contain the ferredoxin/thioredoxin system, was activated by thioredoxins that had been reduced either chemically by dithiothreitol or photochemically by reduced ferredoxin and ferredoxin-thioredoxin reductase. Like their chloroplast counterparts, N. muscorum FBPase and SBPase were activated preferentially by reduced thioredoxin f. SBPase was also partially activated by thioredoxin m. PRK, which was present in two regulatory forms in N. muscorum, was activated similarly by thioredoxins f and m. Despite sharing the capacity for regulation by thioredoxins, the cyanobacterial FBPase and SBPase target enzymes differed antigenically from their chloroplast counterparts. The corresponding enzymes from Chromatium vinosum, an anoxygenic photosynthetic purple bacterium found recently to contain the NADP/thioredoxin sytem, differed from both those of cyanobacteria and chloroplasts in showing no response to reduced thioredoxin. Instead, C. vinosum FBPase, SBPase, and PRK activities were regulated by a metabolite effector, 5′-AMP. The evidence is in accord with the conclusion that thioredoxins function in regulating the reductive pentose phosphate cycle in oxygenic prokaryotes (cyanobacteria) that contain the ferredoxin/thioredoxin system, but not in anoxygenic prokaryotes (photosynthetic purple bacteria) that contain the NADP/thioredoxin system. In organisms of the latter type, enzyme effectors seem to play a dominant role in regulating photosynthetic carbon dioxide assimilation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401986
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  • 10
    facet.materialart.
    Unknown
    Holocene deposits of the northern North Sea evidence for dynamic control of their mineral and chemical composition (1979)
    Kluwer
    In:  Geologie en Mijnbouw, 58 (3). pp. 353-366.
    Details
    Publication Date: 2018-06-06
    Description: Tidal currents and waves have caused some reworking and redistribution of Holocene sediments in the northern North Sea, with preferential deposition of fines in topographic depressions. This has led to a patchy distribution of sediments in terms of their textural, mineralogical and chemical composition. Nevertheless discernable relationships are found to exist between mean grain size and composition of the sediments. The relative abundance of biogenic components (primarily benthic Foraminifera) in the sand-size fraction of the sediments increases as mean grain size decreases, thus biogenic components are relatively more abundant in bathymetric lows. Coarse-grained sediments rich in detrital quartz show higher values of Si/ AI than do fine-grained sediments. Smectite is concentrated in the finest-grained sediments, whereas illite is relatively more abundant in coarser deposits. Thus clay mineral segregation processes previously reported to occur near river mouths also occur in an open shelf environment. Fine-grained, smectite-rich sediments show correspondingly higher values of Fe/ AI and lower values of K/ AI compared to the coarser deposits enriched in illite.
    Type: Article , NonPeerReviewed
    Format: text
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    OceanRep: Article in a Scientific Journal - without review
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