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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 65 (1989), S. 2664-2672 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A capillary-discharge plasma source has been developed to produce a sodium-bearing plasma for fast Z-pinch implosion experiments. Peak currents of 40–50 kA from a 0.5-kJ capacitor bank were driven through a 0.5-mm-diam, few cm long capillary drilled in packed sodium-fluoride powder to form the source. A nozzle was used to collimate plasma ejected from one end of the capillary to produce a 1–2-cm-diam, several cm long cylindrical plasma. Ions with velocities of 2.2–3.4 cm/μs and densities of up to 5×1015 cm−3 were measured with biased charge collectors located at least 5 cm from the nozzle. Measurements of visible light from neutrals near the nozzle exit gave velocities of 1.5–1.7 cm/μs. Indications of axial and radial nonuniformities of the plasma were observed in framing photographs of visible-light emission and in spatially resolved spectral measurements. Neutral-sodium and neutral-fluorine lines were identified in the spectral range from 2300 to 6700 A(ring). Also, impurity lines of carbon, copper, and hydrogen were identified and used to characterize the plasma. Stark broadening of the Balmer alpha line of hydrogen was used to deduce a peak electron density of 8×1016 cm−3 at the exit of a 2-cm-diam nozzle. Electron temperatures of 1.4–1.6 eV at the nozzle exit were inferred from relative intensities of the C i and C ii lines. At this density and temperature, Saha-equilibrium-model calculations indicate that the plasma consists primarily of singly ionized sodium and neutral fluorine. A total mass per unit length (sodium and fluorine) of at least 15 μg/cm is deduced from this analysis of the plasma constituents. This capillary discharge has been used to produce 50–100 GW of sodium K-shell x rays in fast Z-pinch experiments.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 31 (1988), S. 1244-1248 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Spectroscopic measurements of the ion motion in a fast compression high beta tokamak experiment show paramagnetic ion motion. This motion is initially caused by magnetic field gradient drift, which does not produce any net paramagnetic current opposing the plasma diamagnetic current. After the crowbar of the fast rising toroidal magnetic field a larger paramagnetic polarization drift develops, which contributes to the disappearance of the diamagnetic well.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Aquaculture research 17 (1986), S. 0 
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. Three types of circulated systems slocked with tilapia were studied: tanks: miniponds; and ponds. Water was continually circulated and aerated. Daily drainage of non-suspended material was applied in most systems.The continual circulation and resulting resuspension of the organic particular ma Her led to a very high rate of microbial activity. Organic carbon was efficiently metabolized and utilized in the food chain. Inorganic nitrogen was completely oxidized and accumulated in water as nitrates, unlike conventional ponds. The establish men! of an active nitrifying population took, however, a period of about 3 weeks during which high levels of ammonium and nitrite were built up.The water body was continually aerated, yet local anaerobic conditions developed, especially in non-drained tanks or in miniponds where the plastic bottom was covered by a soil layer. Such conditions led to a less efficient organic carbon metabolism, to reduced nitrification and to denitrifcation. Fish growth seemed to be retarded in systems where denitrifcation took place, indicating that the growth-retarding factor is associated with production of anaerobic metabolites in the pond. The role of daily drainage and a proper aeration system is to avoid formation of anaerobic pockets.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Phospholipid-sensitive, Ca++ -dependent protein kinase activity was investigated in the cytosol of melanoma cells, A protein kinase system was partially purified, and enzyme activity was found to be modulated by palmitoyl-carnitine.In order to link the actions of palmitoyl-carnitine on phospholipid-sensitive protein kinase activity and the already reported role of protein kinase C in cell division, we studied the action of palmitoyl-carnitine on melanoma cell growth by measuring colony forming ability in a soft agar culture system. Palmitoyl-carnitine was found to inhibit cell growth in a dose-dependent manner.These findings suggest that palmitoyl-carnitine (or long-chain acylcarnitine), a naturally occurring metabolite, may play a key role in the onset of cell division.We suggest that the action of palmitoyl-carnitine on phospholipid-dependent protein kinase activity is in part related to the molecular events linking protein kinase C activity and the ionic events in the initiation of cell growth.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Retinopathy ; fluorescein angiography ; insulin-dependent diabetes ; children and adolescents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 231 subjects with Type 1 diabetes mellitus aged 17.6 ± 4.0 years, with a diabetes duration of 8.5 ± 4.9 years at the end of the study, the prevalence and the development of retinopathy during a period of 5 years were studied. All patients were examined between one and six times both by ophthalmoscopy and fluorescein angiography. A total of 626 fluorescein angiographies were evaluated. By the end of the study, 109 out of 231 patients (47%) had developed retinal changes, half of which were classified as minimal (〈5 microaneurysms). Thirty-eight patients (35% of those affected) had background (n = 28) or proliferative (n = 10) retinopathy. In subjects less than 15 years of age and diabetic for less than 5 years, retinal lesions were rare. With increasing age and duration of diabetes, both the prevalence and severity of retinal changes increased markedly. Life-table analysis was used to calculate the median individual risk for the development of early retinal changes, which was 9.1 years of diabetes duration. This risk differed in sub-groups with different ages at onset of diabetes, i. e. 12.1, 8.9 and 6.6 years (p 〈 0.0001), with diabetes starting below 4, between 5 and 9, and after 10 years of age respectively. After 18 years of diabetes, every patient demonstrated at least incipient structural changes. Fluorescein angiography allowed the detection of retinopathy, on average, four years earlier than with ophthalmoscopy. The median interval between the ‘onset’ of retinopathy, as indicated by a few microaneurysms, and background retinopathy was 5 years.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 71 (1985), S. 150-154 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A 19-year-old male with azoospermia was found to have a 45,X karyotype with additional euchromatic material on 15p. The parents' karyotypes are normal. The cytogenetic data, the positive H-Y-typing, and the presence of Yp-specific restriction fragments detected in the proband's genome by molecular DNA probes suggest that the short arm of the Y chromosome, including part of the centromere, is translocated onto the nucleolus organizer region (NOR) of chromosome 15.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A patient described as a 45,X male (Forabosco et al. 1977) was examined for the presence of Y-specific DNA by using various probes detecting restriction fragments from different regions of the Y chromosome. Positive hybridization signals were obtained for Yp fragments only. In situ hybridization with two different probes, pDP31 and the pseudoautosomal probe 113F, led to a clear assignment of the Yp sequences to the short arm of one chromosome 18. Cytogenetically, the presence of all of Yp including the Y centromere on 18p could be demonstrated replacing a segment of similar size of 18p. Thus, the Y/18 translocation chromosome is dicentric structurally, but it was shown to be monocentric functionally with the no. 18 centromere active. Gene dosage studies with the probe B74 defining a sequence at 18p11.3 demonstrated a single dose of this sequence in the patient. In agreement with these observations, the patient shows clinical signs of the 18p-syndrome. It is concluded that in XO males in general, the X is of maternal origin while the maleness is due to a de novo Y/autosome translocation derived from the father. Depending on the nature of the autosomal deficiency caused by the Y/autosome translocation, the patient may have congenital malformations.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 147 (1988), S. 59-63 
    ISSN: 1432-1076
    Keywords: Oestrogen treatment ; Height reduction ; Tall girls
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For the treatment of tall stature in girls, oestrogens are usually given in high doses. In this study, growth data of 35 constitutionally tall girls treated with only 0.1 mg/day ethinyl oestradiol (EE) are reported (Group 1). The data were compared with those of 23 untreated girls with comparable bone ages and growth potential (Group 2), and with those of 5 girls treated with 0.3 mg/day EE (Group 3). All groups were followed until cessation of growth. In group 1, the median bone age at the onset of treatment was 12.50 years (Greulich-Pyle, range 10.50–13.75), and the median height prediction was calculated to be 184.4 cm (Bayley-Pinneau, range 179.5–191.5). Following oestrogen treatment of 21 months duration (range 10–37) the median adult height was reduced by 4.3 cm (range 0.0–9.0), or 3.9 cm if corrected for the error of prediction in the control group. The effect was greater in those girls with bone ages below 12.5 years at the onset of treatment (6.7 cm/corrected value 7.4 cm) than in the older girls (4.2 cm/3.6 cm). In Group 2 (controls) the median final adult height was over-estimated by 0.4 cm (range-4.9 to 4.9), but was under-estimated by 0.7 cm in those girls with bone ages below 12.5 years. In girls of comparable bone age similar reductions were obtained whether 0.3 mg/day EE (Group 3) or 0.1 mg/day was given (4.4 vs. 4.2 cm). A comparison of these results with published data indicates that higher EE doses (0.3–0.5 mg/day) have only little, if any, greater effect on the growth of girls than the dosage of 0.1 mg/day EE used in this study.
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  • 9
    ISSN: 1432-1076
    Keywords: Tall stature ; Oestrogen treatment ; Dose dependency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of different doses of oestrogens in constitutionally tall girls were evaluated in two centres for paediatric endocrinology. In one centre, 38 girls were treated with a high oestrogen dose of 0.3 to 0.5 mg ethinyloestradiol (EE) daily. In the other, 44 girls received a comparably low dose of 0.1 mg EE per day. Height prediction (HP), chronological age (CA), and height at the onset of treatment were comparable in both groups. Although the duration of treatment was significantly longer in those receiving the low dose, the cumulative oestrogen dose was still significantly lower. The dose of EE had no effect on final height reduction (high dose group: 4.9±2.6 cm, low dose group: 5.1±2.4 cm). Final height was more reduced in both groups when treatment was started at an early bone age (BA) (≤13 years). No serious side effects were observed in either group, however weight gain was more pronounced in girls receiving the higher dose. We conclude that treatment of constitutionally tall girls with low doses of oestrogens is equally effective in reducing the final height as the usually administered high doses. The lowest effective dose has to be determined in a randomized, prospective clinical trial.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 639-639 
    ISSN: 1435-2451
    Keywords: Arteriosclerosis ; Fracture complication ; Combined therapy ; Chronische arterielle Verschlußkrankheit ; Frakturen ; Komplikationen ; Kombinierte Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1976–1985 wurden 26 Patienten registriert, bei denen sich die periphere Durchblutungssituation unter Frakturenbehandlung verschlechterte. Bei 5 Patienten wurde eine konservative und bei 21 Patienten eine operative Frakturbehandlung durchgeführt. Von den 21 Patienten wurden 4 amputiert, 4 verstarben and bei nur 3 Patienten erfolgte eine Gefäßrekonstruktion. Bei 11 Patienten wurde durch rheologische and konservative Maßnahmen die Extremität erhalten. Kommt es nach konservativer oder operativer Frakturenbehandlung zur Dekompensation einer chronischen AVK, muß das gesamt diagnostische (Angiographie, DSA, Sonographie) and therapeutische Spektrum (rheologische Maßnahmen, Gefäßrekonstruktion, PTA) eingesetzt wurden, um die betroffene Extremität zu erhalten.
    Notes: Summary From 1976 to 1985, a total of 26 patients were recorded who had experienced detoriation in their peripheral circulation under fracture treatment. Conservative treatment of a fracture was carried out in 5 patients and operative treatment in 21. Of the 21 patients, 4 had amputations and 4 died; in only 3 patients was vascular reconstruction possible. By means of rheologic and conservative measures, it was possible to preserve the extremities in 11 patients. If decompensation of a chronic arterial circulatory disturbance occurs, the whole diagnostic (angiography, sonography) and therapeutic spectrum (rheologic measures, vascular reconstruction, percutaneous transluminal angioplasty) must be applied in order to preserve the extremity involved.
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