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  • 1
    Electronic Resource
    Electronic Resource
    Progressive diffuse leukoencephalopathy in patients with acquired immune deficiency syndrome (AIDS) (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 333-339 
    Details
    ISSN: 1432-0533
    Keywords: Acquired immune deficiency syndrome (AIDS) ; Leukoencephalopathy ; Cytomegalovirus ; Papovavirus ; HTLV-III/LAV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two adult patients with acquired immune deficiency syndrome (AIDS) presented with psychoorganic symptoms produced by an extensive cerebral and cerebellar leukoencephalopathy. Diffuse loss of myelin and axons with reactive astrocytosis and distinctive multinucleated giant cells were prominent in the deep white matter, but less so in the subcortical white matter and in compact myelinated pathways. Bilateral involvement of the centrum semiovale produced distal Wallerian degeneration of the descending pyramidal tracts, which in one patient correlated with progressive paraparesis and bladder dysfunction. Although there were morphological indications of cytomegalovirus infection and immunohistochemical evidence of papovavirus antigens, the neuropathology did not resemble that usually associated with infection by these opportunistic agents. The possibility is entertained that the progressive diffuse leukoencephalopathy (PDL) in these patients was directly related to infection with human T-cell lymphotropic virus (HTLV-III/LAV), the etiologic agent of AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690837
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  • 2
    Electronic Resource
    Electronic Resource
    213. Zur Korrektur posttraumatischer Fehlstellungen des distalen Unterschenkels (1985)
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 644-644 
    Details
    ISSN: 1435-2451
    Keywords: Corrective osteotomy ; Lower leg ; Post-traumatic malpositions ; Korrekturosteotomie ; Posttraumatische Fehlstellung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand eigener Untersuchungen nach 67 posttraumatischen Korrekturosteotomien des Unterschenkels wird über Indikation, Technik and Ergebnisse berichtet. Der Eingriff soll mäglichst frühzeitig durchgeführt werden. Er ist technisch anspruchsvoll and muß sorgfältig geplant werden. Die korrigierte Stellung ist durch eine stabile Osteosynthese zu sichern. Bei Rotationsfehlern kann ein einliegender Marknagel mit einem zusätzlichen Implantat verwendet werden. Die adäquate Begleitbehandlung ist für den Erfolg von großer Bedeutung.
    Notes: Summary Indication, surgical methods, and results of corrective osteotomy of the lower leg caused by post-traumatic malpositions are reported in accordance with 67 personally researched cases. The operation should be carried out at an early stage and requires high technical skill and careful planning. The corrected position should be stabilized by a osteosynthesis. If there is rotation failure, an extramedullary nail with minimal additional implant can be used. It is very important for the success of the operation that there be sufcantly competent postoperative care (physiotherapy and/or orthopedic aids).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836812
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  • 3
    Electronic Resource
    Electronic Resource
    219. Quetschverletzungen des Fußes und ihre Therapie (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 762-762 
    Details
    ISSN: 1435-2451
    Keywords: Foot ; Contusion ; Primary treatment ; Fuß ; Quetschung ; Akutversorgung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Quetschverletzungen des Fußes bedürfen eienr sofortigen exakten Therapie in Abhängigkeit von Weichteilschäden und knöchernen Verletzungen. Bei offenen Verletzungen ausgiebiges Debridement, offene Wundbehandlung, sekundär plastische Deckung. Bei knöchernen Verletzungen baldmöglichst offene oder geschlossene Reposition und Stabilisierung, vorzugsweise durch Kirschnerdrähte, evtl. Kombination mit Fixateur externe. Sorgfältige Nachbehandlung, evtl. orthopädische Versorgung. Verbleibende Fehlstellungen bedürfen der Korrekturosteotomie bzw. der Korrekturarthrodese. Anhand von 59 Patienten werden die therapeutischen Möglichkeiten, Komplikationen und Spätergebnisse mitgeteilt.
    Notes: Summary Blunt injuries of the foot may require urgent intervention, depending upon the damage to soft tissues and bony structures. Open injuries require extensive debridement as a second step. Bony lesions should be stabilized after closed or open reduction, preferably with Kirschner wires or external fixation. Late malposition or malunion sometimes requires corrective osteotomy or corrective arthrodesis. The therapeutic options, complications and late results of a follow-up of 59 patients are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274537
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  • 4
    Electronic Resource
    Electronic Resource
    Myocardial elasticity and left ventricular distensibility as related to oxygen deficiency and right ventricular filling. Analysis in a rat heart model (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 537-547 
    Details
    ISSN: 1435-1803
    Keywords: hypoxia ; rigor ; myocardial elasticity ; diastolic ventricular interaction ; rat heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypoxia-induced changes in diastolic left ventricular (LV) pressure volume (P-V) relationships and myocardial elasticity as well as the extent to which diastolic right ventricular (RV) interactions are involved under hypoxia were analysed in male open-chest Wistar rats under isovolumetric conditions. Wall stress σ and differential elastic modulus E were calculated for the midwall region, assuming a spherical model. LV end-diastolic P-V relationship shifted significantly to the left only 2 min after the start of pure N2 ventilation. The slope of the E-σ curve did not change, corresponding to the “contracture type” of decreased myocardial distensibility. Identical changes occurred when filling of the RV was increased under O2 ventilation. Hypoxia, under emptied RV, led within 8 min to substantially lower, nonsignificant steepening of the end-disastolic P-V relationships. There was a significant change in the diastolic P-V curve along with a parallel increase in stiffness constant b, 45 min after N2 ventilation and under emptied RV. However, as a result of failure of cardiac function, ischemia was by now prevailing. These findings led to the following conclusions: In the early phase of hypoxia, i. e. within the first 20 min (in the model used in the present study) no substantial rigor occurs but the increase of LV end-diastolic P-V values is essentially due to augmented RV filling, even under opened chest and removed pericardium. The geometrical influence of the RV mimics the “contracture type” of decreased myocardial distensibility and cannot be recognized on the basis of the E-σ relationship. Without knowledge of RV pressure it is not feasible to distinguish early “contracture” or rigor from extraventricular influences, caused by changes in the filling of the neighbouring ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907917
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  • 5
    Electronic Resource
    Electronic Resource
    Left ventricular end-systolic pressure-volume relationships as a measure of ventricular performance (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 594-607 
    Details
    ISSN: 1435-1803
    Keywords: end-systolic pressure-volume relations ; myocardial performance ; acute impairment of contractility ; spontaneously hypertensive rats ; aorto-caval shunt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The extent to which conclusions about myocardial performance may be drawn from end-systolic pressure-volume relations was investigated. Left ventricular isovolumetric and end-systolic pressure-volume relationships were measured in the rat, under acute impairment of contractility (hexobarbital), at chronic pressure overload (spontaneously hypertensive rats), and at chronic volume overload (aortocaval shunt). Our results confirm the classic conception of Otto Frank where the curves of the isovolumetric maxima and the curves of the end-systolic pressure-volume relations follow separate courses. Acute alterations in contractility can be detected from shifts in the end-systolic pressure-volume relations. In chronic pressure or volume overloaded hearts the end-systolic pressure-volume relations do not render conclusions about ventricular or myocardial performance since in chronically altered hearts, the course of the end-systolic pressure-volume relations is primarily influenced by geometric factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907858
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