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  • 1
    Electronic Resource
    Electronic Resource
    Evolution of cutaneous lymphoid hyperplasia to cutaneous T-cell lymphoma (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 13 (1988), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Single cell DNA measurements have recently been used in diagnosis and as a measure of treatment response in different premalignant and malignant conditions. In the present case evolution of cutaneous lymphoid hyperplasia to cutaneous T-cell lymphoma was demonstrated by histological and immunohistological criteria. However, using single cell DNA measurements clear aneuploidy, by an additional peak in the hyperdiploid region of the DNA histogram, was revealed both in the benign and malignant stages of the disease. Lymph node and peripheral blood were normal by histopathological, immunohistopathological and single cell DNA measurements, indicating that the malignant potential may have been confined to the skin. Thus, single cell DNA measurements may be used as an additional diagnostic tool, when the diagnosis is inconclusive or at variance with the clinical findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1988.tb00711.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistological reactivity pattern of the anti-cutaneous T-cell lymphoma antibody BE2 (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 114 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has been reported that the monoclonal antibody BE2, raised against leukaemic T cells, reacts specifically with malignant lymphoid cells and represents a valuable reagent for the early identification of cutaneous T-cell lymphomas. To test this hypothesis, a comprehensive range of nodal and cutaneous biopsies have been examined immunohistologically using single and double immunoenzymatic and immunofluorescent staining methods. BE2 showed a broad range of reactivity, consistently labelling normal endothelial cells, B-lymphocytes in mantle and marginal zones, T-lymphocytes in the paracortex of lymph nodes and medulla of thymus, as well as a variety of different macrophage types, including Langerhans cells and dermal macrophages. Furthermore, although BE2-positive T-lymphocytes were most frequent in malignant lymphomas, they were also found in four of 19 benign dermatoses. We conclude that BH2 is neither T-cell nor tumour-cell specific, and that use of this reagent on tissue sections is unlikely to improve the diagnosis of cutaneous lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb04875.x
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  • 3
    Electronic Resource
    Electronic Resource
    Single cell DNA measurements in benign cutaneous lymphoid infiltrates and in positive patch tests (1985)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 112 (1985), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cellular DNA in skin biopsies from eighteen patients with positive patch tests and eleven patients with benign lymphocytic skin infiltates (cutaneous lymphocytoma, lymphoplasia or Jessner's lymphotic infiltrate) was estimated by flow cytometry of propidium iodide-stained dermal cells.Specimens from three patients with patch tests and one with cutaneous lymphocytoma had DNA histograms similar to those of normal blood mononuclear cells. The remaining patients demonstrated DNA histogram abnormalities in the form of hyperdiploid peaks in forty-two of forty-five specimens. The estimated proportion of cells in the S-phase was similar in patch tests (median:9.2%) and in benign lymphocytic skin infiltrates (median: 9.6%). The median number of cells in the G2/M-phase was 3.1% in both groups of disorders.These data indicate DNA content heterogeneity of the dermal cells in benign lymphocytic skin infiltrates. This may be attributed to DNA replication and/or chromatin dispersion during cellular activation and proliferation. The data also emphasize that hyperdiploid peaks are not necessarily indicative of the presence of separate cell clones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1985.tb04851.x
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  • 4
    Electronic Resource
    Electronic Resource
    Loco-regionäre Rezidivbehandlung beim Mammakarzinom (1985)
    Springer
    Archives of gynecology and obstetrics 238 (1985), S. 579-580 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02430110
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  • 5
    Electronic Resource
    Electronic Resource
    Activated and cycling lymphocytes in benign dermal lymphocytic infiltrates including psoriatic skin lesions (1985)
    Springer
    Archives of dermatological research 278 (1985), S. 92-96 
    Details
    ISSN: 1432-069X
    Keywords: Dermal lymphocytic infiltrates ; Psoriasis ; Flow cytometry ; DNA measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single-cell DNA measurements obtained using flow cytometry have previously been used as a diagnostic tool for various malignant diseases. We used this technique to characterize the dermal infiltrates of 14 patients with psoriatic skin lesions and 22 patients with various benign skin disorders. The DNA histograms of all of the patients exhibited an increased number of cells showing propidium-iodide fluorescence in the hyperdiploid region as compared to those seen in control DNA histograms of normal blood mononuclear cells. The calculated DNA indices revealed one hyperdiploid (G0/G1) peak in 17 cases and two hyperdiploid (G0/G1) peaks in 13 cases. The results suggest that the dermal lymphocytic infiltrate consists of (1) lymphocytes in the cell-division cycle, (2) non-cycling lymphocytes (G0) and (3) activated lymphocytes that may either remain in a non-cycling state or enter the cell cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409213
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  • 6
    Electronic Resource
    Electronic Resource
    Chronic facial pain following diseases affecting the maxillary antrum (1986)
    Springer
    Acta neurochirurgica 82 (1986), S. 39-42 
    Details
    ISSN: 0942-0940
    Keywords: Facial pain ; peripheral impulses ; maxillary sinusitis ; proximal avulsion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For the purpose of examining the significance of a pain focus in the maxillary air sinus denervation of the mucosa of the sinus by transantral maxillary nerve section was performed. The material comprises 20 patients with pain in the distribution of the infraorbital nerve and previous disease of the relevant sinus. All patients had been treated previously without any benefit from peripheral surgery of the infraorbital nerve. Only 20% had any benefit of the proximal avulsion for more than three months. It is concluded that impulses from the mucosa of the maxillary sinus do not play any part in the occurrence or persistence of facial pain in this highly selected material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01456317
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  • 7
    Electronic Resource
    Electronic Resource
    A continuous T-cell line from a patient with Sézary syndrome (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 293-298 
    Details
    ISSN: 1432-069X
    Keywords: T cells ; Sézary syndrome ; Natural killer cells ; Chromosome aberrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A continuous cell line, Se-Ax, from a patient with Sézary syndrome has been established. The Se-Ax cell line is IL-2 dependent, requires human serum for permanent growth, and has the following phenotype: CD1-, CD2+, CD3+, CD4-, CD5-, CD8-, CD20-, CD25+; it expresses the T9, T10, and HLA-DR antigens. This cell line reveals multiple chromosome aberrations as seen in the most abundant abnormal clone in peripheral blood. Therefore, it is not unlikely that it derives from tumor cells. A putative cytotoxic cell line derived from the same patient has only weak killer-cell activity against the autologous permanent cell line: this CD8+ cytotoxic cell line has a 14q+ chromosomal marker. The fact that the patient demonstrated no natural killer-cell or activated killer-cell activity against the Se-Ax cell line may in part explain the successful establishment of the continuous cell line from bulk culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431220
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