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  • 1985-1989  (3)
Document type
Year
  • 1
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The severity of herpes zoster worsens with age and postherpetic neuralgia is almost limited to the elderly (Wildenhoff et al., 1979, 1981). Acyclovir speeds healing and lessens pain, but has no effect on postherpetic neuralgia (Peterslund et al., 1981; Bean, Braun & Balfour, 1982). Inosine pranobex (or isoprinosine, inosiplex: trade name Imunovir), an immuno-modulator with low toxicity, is effective in herpes simplex (Lancet, 1985). Uncontrolled observations indicate a beneficial effect in herpes zoster (Sternberg & Ruiz, 1972).We report the first double-blind placebo-controlled clinical trial of inosine pranobex in the treatment of herpes zoster and postherpetic neuralgia in the elderly.Forty-two consecutive patients (19 males, 23 females) over 60-years old and in the first 96 h of symptoms were stratified by sex, duration of pain (up to and/or over 48 h) and localization (trigeminal/other) and were randomly allocated 6 days of placebo or of inosine pranobex tablets. Five clinical and five photographic variables were monitored daily for 7–9 days (Peterslund et al., 1981). Pain was assessed monthly for a further 3 months. Investigations at entry, 1 and 4 weeks, comprised haematology, biochemistry, viral culture, immunology, including circulating T-cell subsets, and serology, including ELISA and complement fixation tests.Results, statistically analysed by multiple regression analysis (Peterslund et al., 1981) and life-table techniques, will be presented.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Communications in mathematical physics 118 (1988), S. 401-410 
    ISSN: 1432-0916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract We show that for a surjective endomorphism of a compact abelian group ergodicity is equivalent to a condition which impliesr-mixing for allr≧1, and we characterize such maps algebraically. This is then used in proving the ergodicity of an extensive class of endomorphisms of the binary sequence space. As a simple corollary it is found that one-dimensional linear cellular automata and the accumulator automata arer-mixing for allr≧1.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of engineering mathematics 23 (1989), S. 81-89 
    ISSN: 1573-2703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Technology
    Notes: Abstract A relatively simple continuum model is described for the viscous flow of highly anisotropic materials such as fibre-reinforced resins. The theory is applied to the flow of such a fluid when squeezed between two rigid platens.
    Type of Medium: Electronic Resource
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