Electronic Resource
Springer
Journal of cancer research and clinical oncology
112 (1986), S. 189-195
ISSN:
1432-1335
Keywords:
DNA adducts
;
Cell cycle
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-related genes replicating at critical phases of DNA synthesis, or cell cycle-related differences in the repair of DNA adducts. Some recent data on these subjects are summarized, mainly in context of cell cycle-dependent transformation sensitivity of regenerating rat liver.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00395911
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