ISSN:
1573-4919
Keywords:
La-protein
;
snRNAs
;
scRNAs
;
autoantibody
;
nucleocytoplasmic transport
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Recently we established a monoclonal antibody against the La-protein (Bachmannet al., Proc. Natl. Acad. Sci. USA, 83, 7770, 1986). The antibody gives a nuclear speckled type staining and, in addition, a perinuclear cytoplasmic staining on cultured cells in immunofluorescence microscopy. After inhibition of RNA synthesis the La-protein is transported into the cytoplasm. After prolonged inhibition it returns into the nucleus forming large growing speckles. The transport into the nucleus apparently depends on glycosylation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00577106
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