In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 83, No. S1 ( 1988-05-01), p. S17-S17
Abstract:
PET is an in vivo technique for the measurement of patterns of regional cerebral blood flow (rCBF), metabolic rate for glucose (rCMRGlu), and the uptake of neurotransmitters such as dopamine. Scanning times range from 1 min for rCBF, to 2 h for dopamine, with rCMRGlu scans requiring 1 h. Studies of rCMRGlu in patients with movement disorders and dysarthria have demonstrated correlations between voice onset time abnormalities and rCMRGlu in the basal ganglia; similar studies with dopamine are currently in progress. Because of the shorter scan time, rCBF studies are better suited for perceptual studies. Using a steady-state C0150 inhalation technique, 14 1-min scans can be obtained back-to-back. The C0150/PET has been used to study rCBF patterns in within-subject studies that include both stimulated and unstimulated periods, with stimuli such as broadband white noise, music, and complex tones in a pitch discrimination task. Results to date demonstrate that both regional and global changes are associated with stimulation states. PET provides a unique technique for studying human cerebral physiology associated with auditory perception and speech production. [Work supported by NIH.]
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
1988
detail.hit.zdb_id:
1461063-2
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