In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 9, No. 4 ( 1989-08), p. 461-470
Abstract:
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15 O-labelled water during the continuous inhalation of 15 O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques.
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1038/jcbfm.1989.69
Language:
English
Publisher:
SAGE Publications
Publication Date:
1989
detail.hit.zdb_id:
2039456-1
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