In:
The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 15, No. 01n02 ( 1987-01), p. 43-51
Abstract:
The water extract of Hsien-Ho T'sao (HHT) prolonged the tail bleeding time in conscious mice. This antihemostatic effect was dose-dependent and exhibited a biphasic pattern; i.e. its activity declined at doses higher than 0.5 mg/kg, the prolonged bleeding time persisted for at least 12 hr and maxmial effect was observed at 3 hr after the oral adminstration of HHT 500 mg/kg. HHT was effective in preventing ADP-induced acute pulmonary thromboembolic death in mice, while aspirin and indomethacin had no effect on this model. HHT, lik aspirin and indomethacin, also reduced the mortality in collagen- and sodium arachiodonate-induced thromboembolic death. All three drugs caused no significantn protection in endotoxin shock. HHT was found to suppress platelet aggregation markedly, but little effect on blood coagulation. In conclusion, HHT was proved to be efective in the treatment of acute pulmonary throboembolism, and this effect was mainly due to its antiplatelet action.
Type of Medium:
Online Resource
ISSN:
0192-415X
,
1793-6853
DOI:
10.1142/S0192415X87000060
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
1987
Permalink