In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 108, No. 4 ( 1985-04), p. 565-569
Abstract:
Abstract. In order to evaluate the effect of hyperprolactinaemia on gonadal function in men, testicular stimulation by human chorionic gonadotrophin (hCG) (5000 IU/day, 3 consecutive days) was performed on 6 men with chronic hyperprolactinaemia and 6 control subjects. The following parameters were measured before and during the 4 consecutive days following the injections of hCG: the concentration in plasma of testosterone (T), oestradiol-17β (E 2 ), dihydrotestosterone (DHT) and the urinary excretion of testosterone glucuronide (TG) and 5α-androstane-3α,17β-diol glucuronide (3α-DiolG). The rises in T, E 2 , DHT and the ratios of T/DHT and TG/3α-Diol G were similar in both groups, but the rises in TG and 3α-Diol G were lower in the hyperprolactinaemic group after hCG. There was no correlation between the response of T and the increment of E 2 in either group. It is suggested that in men with chronic hyperprolactinaemia: 1) there is diminished testicular response to hCG; this could be due to chronic gonadotrophin deficiency or to a direct effect of hyperprolactinaemia on the testes, 2) there is no modulation of T synthesis through inhibition of aromatase activity and E 2 secretion and 3) the 5α-reduction of T is not deficient.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.1080565
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1985
detail.hit.zdb_id:
1485160-X
Permalink