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  • 1
    Online Resource
    Online Resource
    Canadian Science Publishing ; 1987
    In:  Canadian Journal of Chemistry Vol. 65, No. 7 ( 1987-07-01), p. 1513-1520
    In: Canadian Journal of Chemistry, Canadian Science Publishing, Vol. 65, No. 7 ( 1987-07-01), p. 1513-1520
    Abstract: A series of monopiperidine, 1, dipiperidine 2, 3 (syn and and), as well as the corresponding oxazoline and oxazolidine crown ethers have been prepared and their ionophoric properties evaluated. The syn-dipiperidine 2c turned out to be a particularly efficient Ca 2+ ligand (log K = 9.7). 13 C and 23 Na nuclear magnetic resonance spectroscopy was used to evaluate the nature of the complex between the monopiperidine 1c, the syn-dipiperidine 2c, and Ca 2+ and Na + ions. In methanol–water solution, the dimeric salt (2c) 2 Ca exhibits both a tight or asymmetric and a symmetric or loose ion pair between the cation and the carboxylate groups. Sodium-23 chemical shifts and line-width variation both support a 1:1 complex with 1c and 2c. The structural results correlate with observations from ion transport experiments.
    Type of Medium: Online Resource
    ISSN: 0008-4042 , 1480-3291
    RVK:
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1987
    detail.hit.zdb_id: 1482256-8
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 1988
    In:  Behaviour Research and Therapy Vol. 26, No. 3 ( 1988), p. 275-277
    In: Behaviour Research and Therapy, Elsevier BV, Vol. 26, No. 3 ( 1988), p. 275-277
    Type of Medium: Online Resource
    ISSN: 0005-7967
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1988
    detail.hit.zdb_id: 1499890-7
    detail.hit.zdb_id: 211997-3
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Elsevier BV ; 1989
    In:  Immuno-analyse & Biologie Spécialisée Vol. 4, No. 1 ( 1989-4), p. 31-34
    In: Immuno-analyse & Biologie Spécialisée, Elsevier BV, Vol. 4, No. 1 ( 1989-4), p. 31-34
    Type of Medium: Online Resource
    ISSN: 0923-2532
    Language: French
    Publisher: Elsevier BV
    Publication Date: 1989
    detail.hit.zdb_id: 2028854-2
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  • 4
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 1989
    In:  Journal of Animal Science Vol. 67, No. 9 ( 1989-09-01), p. 2309-2315
    In: Journal of Animal Science, Oxford University Press (OUP), Vol. 67, No. 9 ( 1989-09-01), p. 2309-2315
    Type of Medium: Online Resource
    ISSN: 0021-8812 , 1525-3163
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1989
    detail.hit.zdb_id: 1490550-4
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Elsevier BV ; 1988
    In:  The Lancet Vol. 331, No. 8587 ( 1988-03), p. 715-
    In: The Lancet, Elsevier BV, Vol. 331, No. 8587 ( 1988-03), p. 715-
    Type of Medium: Online Resource
    ISSN: 0140-6736
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1988
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 6
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 1985
    In:  Neurology Vol. 35, No. 2 ( 1985-02-01), p. 192-192
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 35, No. 2 ( 1985-02-01), p. 192-192
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1985
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  • 7
    Online Resource
    Online Resource
    The American Association of Immunologists ; 1988
    In:  The Journal of Immunology Vol. 141, No. 12 ( 1988-12-15), p. 4344-4351
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 141, No. 12 ( 1988-12-15), p. 4344-4351
    Abstract: Both the activation and the transformation of human B cells by EBV were inhibited by either the Ca2+ channel blocking agent verapamil or the combination of theophylline and dibutyryl cAMP: the day 4 and day 20 peaks of [3H]TdR incorporation were a bolished; the EBNA marker was not expressed by day 10; lymphoblastoid cell lines did not arise. Short term incubation of B cells with EBV or verapamil showed that the effect of verapamil was reversible and took place early in the interaction between EBV and B cells. The effect of EBV on the early metabolic events of B cell response was thus examined in the presence and in the absence of the drugs. Compared to anti-mu stimulation, supernatant of the transforming B95-8 strain as well as that of the non-transforming P3HR1 strain induced a drug sensitive increase of the free cytosolic Ca2+ concentration. This increase was associated with a protein kinase C translocation from the cytosol to a membrane bound compartment. Moreover, B95-8 supernatant induced phosphatidyl inositol metabolism by human B cells but at least four times less than that induced by anti-mu antibody. These metabolic events induced by EBV were significantly inhibited by anti-CD21 antibodies whereas anti-mu induced metabolic events were not. The infection of EBV negative Ramos cell line was prevented by verapamil or by theophylline + dibutyryl cAMP. Verapamil did not modify the density of EBV receptors but negatively interfered with the penetration of the virus into B cells. Thus B cell activation through the EBV receptor and virus penetration share a common metabolic pathway which is also used for transduction of the signal delivered through the membrane Ig.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    RVK:
    RVK:
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 1988
    detail.hit.zdb_id: 1475085-5
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  • 8
    Online Resource
    Online Resource
    Wiley ; 1989
    In:  The Journal of Physiology Vol. 411, No. 1 ( 1989-04-01), p. 611-626
    In: The Journal of Physiology, Wiley, Vol. 411, No. 1 ( 1989-04-01), p. 611-626
    Type of Medium: Online Resource
    ISSN: 0022-3751
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 1989
    detail.hit.zdb_id: 1475290-6
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 1989
    In:  Planta Vol. 179, No. 3 ( 1989-10), p. 387-396
    In: Planta, Springer Science and Business Media LLC, Vol. 179, No. 3 ( 1989-10), p. 387-396
    Type of Medium: Online Resource
    ISSN: 0032-0935 , 1432-2048
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1989
    detail.hit.zdb_id: 1463030-8
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1988
    In:  Psychiatry and Psychobiology Vol. 3, No. 2 ( 1988), p. 87-98
    In: Psychiatry and Psychobiology, Cambridge University Press (CUP), Vol. 3, No. 2 ( 1988), p. 87-98
    Abstract: Our study involved a statistical comparison of two groups of patients with ano rexia nervosa (according to DSM-III criteria) - below the age of 13, above the age of 13 - who were examine at a child and adolescent psychiatry clinic. It showed the following resuits. 1) Anorexia nervosa is not very frequent among children who are less than 13 years of age, in comparison with) adolescents; indeed the younger group comprises 14 patients over a period of 7.5 years, whereas the older group includes 37 patients over a period of 2.5 years. 2) The proportion of boys is higher in the younger group (below 13) since we find 5 boys and 9 girls, boys repre senting 35% of this group; the predominance of girls over boys is more clear at puberty since we have one boy; for 36 girls, with boys representing only 3% of the older group. 3) Growth delays are marked in young anorexic patients. In our series, only boys were affected by it (3). The age of onset was 10 years for the first one and 11.5 for the other 2. Two patients had reached their final height which was normal. The third patient had a height below - 2 SD at age 23. One can question the absence of growth delay in our younger female series. In our opinion, the reason is that our anorexic girls were older than 10 year. of age at the time of onset of the illness. Their growth was then well-advanced and they were likely to have started their puberty. In contrast, those boys with growth arrest were all prepubertal at the time of onset of the anorexia, disorder. 4) The clinical symptomatology is more spectacular in the younger group: – a premorbid State characterized by eating problems during early childhood; – a rapid weight loss. Weight is often below 25% of the previous one but thinness is pronounced, as there is little fat tissue before puberty. In the young group, the weight loss is generally between 15 and 20%; – in 3 cases out of 14, hydration refusal was associated with food refusal; this particulur symptom was not observed in the older group. These last two observations challenge the appropriateness of DSM-III criteria for anorexia nervosa in young children. 5) In contrast, there was no significant difference between the 2 groups regarding: the frequency of psychiatric disorders among parents and siblings: 17,8% in parents of group I, primarily affective disorders (16%). Eating disorders was the most often diagnosed pathology among our patients’ siblings; the position of the anorexic patient within the sibling System, the social status of parents, the situation of the parental home; physical hyperactivity, occurrence of induced vomiting, use of laxatives and Somatic complaints; prevalence of depression as an associated diagnosis; it is fairly high in both groups since we find 86% with depression in the younger group (12 out of 14) and 60% in the older group (22 cases out of 37); severity of psychosocial stress; the level of adjustment and of academic and social functioning during the past year. Among the various adjustment problems observed in many of our anorexic patients, we find social relationship problems as well as cognitive distortions which lead to poor academie achievement in spite of adequate intellectual potential and overinvolvement in scholl work. 6) Our conclusions concerning the outcome of anorexia are incomplete because of a lack of precision in some of the data collected, the relatively brief duration of follow-up (patients front group I generally benefited front a more regular and prolonged follow-up - an average of 4 years - than patients front groupe 2 - average of 2 years) and because of the sampling weaknesses of the younger group. Weight returned to normal in 78.5% of the cases of group 1 and 54% of the cases of group 2. We noted that it is relatively easy to produce weight gains in anorexic patients. Eating behavior was adequate in 1 subject of group 1 (64%) and 19 subjects of group 2 (51%). Appearance or reappearance of menses are observed in 6 girls out of 9 in group 1 (66.6%) and 20 girls out of 36 in group 2 (55.5%). An evaluation of our subjects mental status (only 12 out of 14 subjects were involved since 2 did not respond to our questions) shows that one female patient presents with chronic anorexia nervosa, involving recurrent episodes of major depression; another female patient had a delusional episode of depression; a third one can be considered as being schizophrenic. Six subjects suffer from chronic anxiety with lack of self-confidence and social phobia for one of them. The last three function adequately in all areas. As we can see, anorexia nervosa is a serious illness with an uncertain prognosis. However, there did not seem to be any difference between the two groups with regard to the evolution of the disease (front a behavioral standpoint). However, we should stress that except for 2 cases, anorexic patients below the age of 13 had been affected by the disorder right before puberty or soon after its beginning.
    Type of Medium: Online Resource
    ISSN: 0767-399X , 2633-0903
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1988
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