In:
International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 1, No. 2 ( 1988-05), p. 115-118
Abstract:
Adriamycin-induced histamine release has been studied on purified mast cells obtained from peritoneal cavities of mice and rats. The activity of the antineoplastic drug was compared with that of the classic basic secretagogue compound 48/80. Rat and mouse mast cells were similarly responsive to adriamycin, on the contrary, the activity of compound 48/80 was more marked in rat than in mouse. The antianaphylactic agent sodium cromoglycate was extremely effective in preventing adriamycin-induced histamine release in both species, whereas, an inhibitory activity against compound 48/80 was evident only in rat mast cells.
Type of Medium:
Online Resource
ISSN:
2058-7384
,
2058-7384
DOI:
10.1177/039463208800100203
Language:
English
Publisher:
SAGE Publications
Publication Date:
1988
detail.hit.zdb_id:
2505963-4
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