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  • Clorgyline  (2)
  • Rheumatoid Arthritis  (2)
  • Aging, Heart Failure, Cardiovascular Surgery, Coronary Artery Disease
  • 1985-1989  (4)
Document type
Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Fenfluramine-induced suppression of food intake and locomotor activity is differentially altered by the selective type A monoamine oxidase inhibitor clorgyline (1988)
    Springer
    Psychopharmacology 95 (1988), S. 313-317 
    Details
    ISSN: 1432-2072
    Keywords: Food intake ; Locomotor activity ; Fenfluramine ; Clorgyline ; Long-term ; Suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of fenfluramine to rats produced decreases in 1-h food intake and locomotor activity. Short-term (2–6 days) or long-term (21–25 days) treatment with the monoamine oxidase (MAO) type A inhibiting antidepressant clorgyline potentiated fenfluramine-induced suppression of food intake but did not affect fenfluramine-induced suppression of locomotor activity. Although daily (4 h) food intake was not significantly less in clorgyline-treated animals relative to saline-treated controls, body weight gain was significantly less in clorgyline-treated animals relative to controls. These findings demonstrate a differential effect of clorgyline treatment on fenfluramine-induced suppression of food intake and locomotor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181939
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperthermia induced by m-CPP in the rat and its modification by antidepressant treatments (1989)
    Springer
    Psychopharmacology 97 (1989), S. 269-274 
    Details
    ISSN: 1432-2072
    Keywords: m-CPP ; Temperature ; Clorgyline ; Clomipramine ; Imipramine ; Antidepressant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of the serotonin agonist m-chlorophenylpiperazine to rats produced a dose-related hyperthermia. Pretreatment with the serotonin receptor antagonist metergoline totally abolished this response, whereas similar treatment with haloperidol, phenoxybenzamine, naloxone, clonidine, pindolol, propranolol, methiotepin, and ritanserin was ineffective. In studies investigating the modification of the response by antidepressant treatments both acute (3 day) and chronic (22 day) administration of the MAO inhibitor clorgyline, as well as the tricyclics clomipramine and imipramine, attenuated the hyperthermic response to m-CPP. These findings are discussed with regard to the specificity of m-CPP-induced hyperthermia and its subsequent modification by antidepressant treatments, in order to evaluate this model's use as a probe for assessment of the serotonergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442262
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Keratoconjunctivitis sicca in rheumatoid arthritis (1988)
    Springer
    Clinical rheumatology 7 (1988), S. 237-241 
    Details
    ISSN: 1434-9949
    Keywords: Keratoconjunctivitis Sicca ; Sjögren's Syndrome ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The prevalence of keratoconjunctivitis sicca (KCS) was studied in a randomly selected group of 104 patients with rheumatoid arthritis (RA). Symptoms of KCS were noted in 33 patients (31.7%) and they were studied further. After rose bengal staining, 22 of these patients were found to have KCS which was diagnosed by the presence of corneal or conjunctival desiccation. The overall prevalence of KCS was 21.2%. Although an abnormal Schirmer's test was noted in 21 of the 22 patients with KCS, only 8 patients had values of 5 mm or less while the remainder had a mild abnormality ranging from 6 to 15 mm. A reduced marginal tear film was noted in 15 patients (68.2%) with KCS and 13 patients (59%) had a reduced tear break-up time. The Schirmer's test alone is inadequate to make a definite diagnosis of KCS and it is essential to perform slit lamp examination to detect epithelial staining with rose bengal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02204461
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A clinical and biochemical assessment of etidronate disodium in patients with active rheumatoid arthritis (1988)
    Springer
    Clinical rheumatology 7 (1988), S. 91-94 
    Details
    ISSN: 1434-9949
    Keywords: Etidronate ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diphosphonates reduce the rate of bone turnover. They have additional pharmacological properties improving adjuvant arthritis in rats and lowering ESR in this condition. We have evaluated etidronate disodium, a diphosphonate commonly prescribed in the United Kingdom for Paget's disease in patients with rheumatoid arthritis. Apart from an early improvement in articular index, perhaps reflecting anti-inflammatory activity, no significant change occurred in clinical variables or in laboratory indices of ‘secondline’ action at a dose of 5 mg/kg/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284063
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    Paper (German National Licenses)
    Fulltext
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