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  • Inorganic Chemistry  (2)
  • insulin  (2)
  • 24-h blood pressure monitoring  (1)
  • Adenosine deaminase deficiency  (1)
  • Apparat  (1)
  • 1985-1989  (7)
Document type
Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Insulin stimulates skeletal growth in vivo and in vitro —— comparison with growth hormone in rats (1989)
    Springer
    Diabetologia 32 (1989), S. 198-202 
    Details
    ISSN: 1432-0428
    Keywords: Skeletal growth ; somatomedin ; insulin ; growth hormone ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of insulin on skeletal growth was examined by (1) systemic injection, (2) local administration into the tibia growth plate and (3) in vitro by use of chondrocytes in culture. (1) Male rats, body weight 60–75 g, were hypophysectomised. One week after the operation, the animals were divided into three groups. Group A received intraperitoneally saline, group B insulin (5–30 U·kg−1·day−1) and group C human growth hormone (250 μg/kg/day) for the following 10 days. In addition, on day 10 the rats were injected with 10 μCi 35-S-sulfate intraperitoneally. Twenty-four h later in the non-fasting state plasma glucose, insulin, somatomedin activity (porcine assay), body weight, nose-rump length, width of the tibia growth plate, and the 35-S-sulfate incorporation into rib cartilage were determined. Compared to saline, growth hormone and insulin treatment significantly enhanced body weights, nose-rumb lengths, the widths of the proximal tibia growth plates and the incorporation of sulfate into rib cartilage. For the three skeletal growth parameters, growth hormone was more effective than insulin, while body weights did not differ after insulin or growth hormone treatment. So matomedin activity (U/ml) was low in group A (0.39±0.04, n=9, Mean±SEM) and group B (0.34±0.08, n=8) and high in the growth hormone treated group C (0.90±0.09, n=7; p〈0.002). (2) To test the possibility that insulin might directly augment skeletal growth, insulin (80 mU) was injected into the proximal tibia growth plate of one leg and saline into the cartilage zone of the other leg. Insulin treatment significantly increased the width of the cartilage zones. Insulin: 211±22 μm, saline 200±22 μm, (Mean±SD, n=6, p〈0.05). (3) Addition of human biosynthetic insulin and growth hormone to the culture medium increased colony formation of chondrocytes in a bell-shaped fashion. A plateau in colony formation was reached with 3.1–6.25 ng/ml insulin and 25–50 ng/ml growth hormone, but with larger dosages of both hormones, the effect was diminished. The results suggest that insulin might stimulate postnatal skeletal growth by a direct effect on the target cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265094
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  • 2
    Electronic Resource
    Electronic Resource
    Diurnal variations of blood pressure in shift workers during day and night shifts (1989)
    Springer
    International archives of occupational and environmental health 61 (1989), S. 463-466 
    Details
    ISSN: 1432-1246
    Keywords: Shift work ; Night shift ; Blood pressure ; 24-h blood pressure monitoring ; Circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The dependence of blood pressure upon internal rhythms and the short-term effects of shift rota on the blood pressure were investigated in shift workers. Blood pressure was measured every 30 min using automatic recorders for 24 h in 17 physically working men in a chemical factory during their morning and night shifts. Mean 24-h blood pressures were identical in the morning and night shifts. There were no differences of the mean blood pressure between the respective sleeping phases or between the working periods. The amplitudes of circadian blood pressure variations were equal. There was a phase difference of 8 h corresponding to the lag between the working periods. At this 8-h lag the hourly means of the 24-h blood pressure were closely correlated (r = 0.69). Comparisons of 24-h blood pressure profiles during the first and last days of a night shift week showed that the effects of night work on the blood pressure were already fully developed within the first 24h (r = 0.86). Thus the diurnal variations of the blood pressure are determined by the working and sleeping periods and largely independent of endogenous rhythm. There is no short-term alteration of the mean 24-h blood pressure after shift rota.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386480
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  • 3
    Electronic Resource
    Electronic Resource
    HLA-haploidentical bone marrow transplantation in three infants with adenosine deaminase deficiency: Stable immunological reconstitution and reversal of skeletal abnormalities (1989)
    Springer
    European journal of pediatrics 149 (1989), S. 104-109 
    Details
    ISSN: 1432-1076
    Keywords: Adenosine deaminase deficiency ; HLA-haploidentical bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three infants with severe combined immunodeficiency and adenosine deaminase (ADA) deficiency were treated by T-cell depleted bone marrow transplantation (BMT), using human leukocyte antigen (HLA)-haploidentical parents as donors. In the first patient, two initial transplants failed to engraft and no change of the immunodeficiency was observed. In order to overcome this graft resistance, cytoreductive conditioning was used prior to a third transplant. In the other two patients, similar conditioning was used prior to initial transplants. In all three patients, complete and permanent immunological reconstitution was observed and they survive from 3.5 to 5 years after transplantation. In biopsies obtained from iliac bones prior to BMT, osteochondral abnormalities characteristic of ADA-deficiency were noted in all three patients. After successful transplantation, these abnormalities had completely resolved. Our results demonstrate that cytoreductive conditioning prior to HLA-haploidentical BMT is useful in order to obtain stable engraftment and reversal of abnormalities associated with ADA deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995857
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  • 4
    Electronic Resource
    Electronic Resource
    Insulin-like growth factors and insulin increase the contractility of neonatal rat cardiocytes in vitro (1988)
    Springer
    Basic research in cardiology 83 (1988), S. 647-654 
    Details
    ISSN: 1435-1803
    Keywords: neonatal ratcardiocytes ; IGF ; insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the newborn several situations of hyperinsulinism can be associated with myocardial hypertrophy and increased contractility. Insulin and the insulin-like growth factors (IGF) are derived from a common ancestral molecule. Insulin exerts mainly metabolic action, whereas the IGFs promote cell multiplication and differentiation. Using an assay system of cultured neonatal myocardial cells the stimulatory action of insulin and the insulin-like growth factors I and II on myocardial cell contractility was investigated. Spontaneously beating aggregates of myocardial cells were synchronized by an electric impulse generator. Contractility was measured via the amplitude of contraction by an optoelectronic system. Insulin at a concentration of 6,250 and 12,500 μU/ml increased the contractility by 11 and 18%; IGF-I at a concentration of 12 and 25 ng/ml, and IGF-II at a concentration of 25 and 50 ng/ml increased the contractility by 16 and 22%, and 13 and 18%, respectively. Lower concentrations did not provoke a significant increase in contractility. Insulin only in supraphysiological doses increases the contractility of neonatal myocardial rat cells, whereas both insulin-like growth factors act in physiological concentrations. Therefore, during hyperinsulinism insulin may increase myocardial contractility via the IGF receptor and not via the insulin receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01906959
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  • 5
    Electronic Resource
    Electronic Resource
    Synthese von [2]-Catenanen aus [2]-Rotaxanen (1988)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 121 (1988), S. 961-970 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthesis of [2]-Catenanes from [2]-RotaxanesStarting from the rotaxane 18a a mixture of catenane 21 and rotaxane 23 is obtained by attaching a polymethylene bridge between the methylene groups in α-position of the sulfonyl groups. The isocyclic catenane 28 containing a 28- and a 46-membered ring is obtained from the catenane 21 by splitting the bonds between the bridgehead atoms and the sulfonyl groups. The 1H-, 13C-NMR, and mass spectra of this compounds are discussed.
    Notes: Ausgehend von dem Rotaxan 18a wird durch Angliederung einer Polymethylenbrücke zwischen den beiden zu den Sulfonylgruppen α-ständigen Methylengruppen ein Gemisch von Catenan 21 und Rotaxan 23 synthetisiert. Aus 21 wird nach Spaltung der Bindungen zwischen den Brückenkopfatomen und den Sulfonylgruppen das isocyclische Catenan 28, bestehend aus einem 28-und einem 46-gliedrigen Ring, erhalten. Die 1H-, 13C-NMR-Spektren und Massenspektren dieser Verbindung werden diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19881210522
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  • 6
    Electronic Resource
    Electronic Resource
    Gezielte Synthese von translationsisomeren [3]-Catenanen (1986)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 119 (1986), S. 1374-1399 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Directed Synthesis of Translationally Isomeric [3]-Catenanes1)In a multi-step reaction sequence the tetrahydroxymetacyclophane 12c is synthesized. Acetalisation with 1,25-dichloro-13-pentacosanone followed by nitration and reduction afforded the diamine 13c. By cyclization of this compound in 2-pentanol with sodium carbonate and sodium iodide under high dilution conditions the monomeric products 16, 17, and 18 are obtained in yields of 21.4, 7.7, and 0.9%, respectively. On the basis of mass, 13C NMR and 1H NMR spectra the structure of these compounds is discussed. Starting from the precatenane 16 the [3]-catenanes 25a, b,c and 26a, b, c are obtained in a multi-step reaction sequence. The structure of these compounds is confirmed by mass, 13C NMR, and 1H NMR spectroscopic investigations.
    Notes: In einer vielstufigen Synthese wird das Tetrahydroxymetacyclophan 12c synthetisiert. Durch Acetalisierung mit 1,25-Dichlor-13-Pentacosanon, nachfolgender Nitrierung und Reduktion wird das Diamin 13c erhalten. Dessen Cyclisierung in 2-Pentanol in Gegenwart von Natriumcarbonat und Natriumiodid unter Verdünnungsbedingungen ergibt die monomeren Cyclisierungsprodukte 16, 17 und 18 in Ausbeuten von 21.4. 7.7 und 0.9%. Die Struktur dieser Verbindungen wird anhand der Massen-, 13C- und 1H-NMR-Spektren diskutiert. In einer mehrstufigen Reaktionsfolge werden aus dem Prä-[3]-catenan 16 die [3]-Catenane 25a, b, c und 26a, b, c erhalten. Die Struktur dieser Verbindungen wird durch 13C-NMR, 1H-NMR- und massenspektroskopische Untersuchungen bewiesen.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19861190424
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  • 7
    Electronic Resource
    Electronic Resource
    Lokale Lasteinleitung in Zylinderschalen des Apparatebaus (1986)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 58 (1986), S. 442-443 
    Details
    ISSN: 0009-286X
    Keywords: Apparat ; Druckbehälter ; Zylinderschale ; Lagerung ; Abstützung ; Tragelement ; Tragpratze ; Zusatzkräfte ; lokale Belastungen ; Spannungen ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330580528
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