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  • SAGE Publications  (2)
  • 1985-1989  (2)
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  • SAGE Publications  (2)
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  • 1985-1989  (2)
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  • 1
    Online Resource
    Online Resource
    A Comparison of Defective Platelet Count and Aggregation between the Valve Replacement and Cyanotic Congenital Heart Cases during Cardiopulmonary Bypass
    SAGE Publications ; 1987
    In:  Perfusion Vol. 2, No. 2 ( 1987-04), p. 87-95
    Details
    In: Perfusion, SAGE Publications, Vol. 2, No. 2 ( 1987-04), p. 87-95
    Abstract: Platelet count and ADP-induced platelet aggregation were studied in 10 single valve replacement (VR) patients and 10 cyanotic congenital heart disease (CCHD) patients undergoing cardiopulmonary bypass (CPB). The mean platelet count dropped to 78% in VR group and 73% in CCHD group at 30 minutes CPB as compared with the prebypass levels (being corrected for haemodilution). The mean prebypass platelet aggregation value was 65·5% ± 7·5% (Mean ± SEM) in VR group and 56·5% ± 5·2% in CCHD group; the values dropped to 54·2% ± 4·5% and 28·2% ± 4·8% respectively in VR and CCHD groups ( P 〈 0·01) at 30 minutes CPB. Both groups had a slight further drop at the end of the CPB, but only CCHD group had a further drop in platelet aggregation function after protamine administration. Mean plasma haemoglobin was much higher in the CCHD group than that in VR group at the termination of the bypass ( P 〈 0·05). Increased blood transfusion volumes were needed and greater blood losses noticed in the CCHD group. A significant negative correlation ( r = 0·5044. P 〈 0·05) was found between platelet function measured at the termination of CPB and postoperative bleeding. Cardiopulmonary bypass in patients with CCHD appears to be associated with greater platelet dysfunction and this results in more serious haemostatic defects after CPB. It is necessary to have further studies of the defective haemorrhagic status in these patients. More advanced perfusion techniques should be applied to preserve platelets during cardiopulmonary bypass.
    Type of Medium: Online Resource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/026765918700200202
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1987
    detail.hit.zdb_id: 2029611-3
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Removal of Unconjugated Bilirubin by Macroreticular Resin in Hemoperfusion
    SAGE Publications ; 1986
    In:  The International Journal of Artificial Organs Vol. 9, No. 5 ( 1986-09), p. 323-326
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 9, No. 5 ( 1986-09), p. 323-326
    Abstract: Macroporous polystyrene and polyvinylpyridine beads with quaternary ammonium and tertiary groups were tailor-made for the adsorption of unconjugated bilirubin. In vitro studies in order to obtain high adsorption capacity, the synthesized macroporous resin should have an average pore size of about 160 Å and with surface area as large as possible. As the crosslinking of the resin increased from 4%-40% the amount of bilirubin adsorbed increased from 0.17 mg/g to 2.0 mg/g. Resins containing strong basic groups have higher adsorption capacities than their corresponding weak base groups. Adsorption mechanism studies showed that both chemical and physical adsorption took place. Adsorption of bilirubin in plasma was some what lower than in buffer solution.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139888600900512
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1986
    detail.hit.zdb_id: 1474999-3
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