In:
Neonatology, S. Karger AG, Vol. 52, No. 3 ( 1987), p. 157-165
Abstract:
We have recently demonstrated that intramuscular administration of triiodothyronine (T 〈 sub 〉 3 〈 /sub 〉 ) or thyroxine (T 〈 sub 〉 4 〈 /sub 〉 ) to the rabbit doe results in its transfer across the placenta. In this study we investigated the effect of maternally administered T 〈 sub 〉 3 〈 /sub 〉 upon the functional and morphologic fetal lung maturation. T 〈 sub 〉 3 〈 /sub 〉 (175 μg/kg) or the vehicle was injected intramuscularly into the New Zealand White rabbit does on days 25 and 26 of gestation. On day 27 of pregnancy, the does were killed and the fetuses were delivered. Maternal and fetal plasma T 〈 sub 〉 3 〈 /sub 〉 , glucose and insulin and fetal plasma corticosteroid concentrations were determined. The functional pulmonary maturity was assessed by performing the pressure-volume hysteresis while morphologic maturity was established by histologic techniques. Enhanced functional as well as morphologic fetal lung maturation was observed in female as well as male fetuses in T 〈 sub 〉 3 〈 /sub 〉 -treated aninmals. However, there was a significant increase in the fetal mortality after T 〈 sub 〉 3 〈 /sub 〉 treatment, and the duration of survival in the extrauterine environment on premature delivery was not prolonged.
Type of Medium:
Online Resource
ISSN:
1661-7800
,
1661-7819
Language:
English
Publisher:
S. Karger AG
Publication Date:
1987
detail.hit.zdb_id:
2403535-X
SSG:
12
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