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  • 1
    Electronic Resource
    Electronic Resource
    Crystallography of highly substituted galactomannans: fenugreek and lucerne gums (1989)
    s.l. : American Chemical Society
    Macromolecules 22 (1989), S. 2641-2644 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00196a017
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  • 2
    Electronic Resource
    Electronic Resource
    Illustrated glossary for spinal anatomy (1985)
    Springer
    Rheumatology international 5 (1985), S. 241-245 
    Details
    ISSN: 1437-160X
    Keywords: Spine ; Anatomy ; Nomenclature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors define, explain, and illustrate a number of concepts pertaining to normal spinal anatomy that are of practical use but omitted in standard anatomical sources or are the subject of conflicting views: bony and cartilaginous end-plate, marginal ring, cortex of the vertebral body, isthmus, neurocentral junction, uncus, uncovertebral joint, zygapophyseal joint, annulus fibrosus, shorter and longer perivertebral ligaments, interspinous bursa, mamillo-accessory ligament. A French and German translation of recommended terms is provided as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541350
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  • 3
    Electronic Resource
    Electronic Resource
    Patterns of the cosmic microwave background from evolving string networks (1988)
    [s.l.] : Nature Publishing Group
    Nature 335 (1988), S. 410-414 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A network of cosmic strings generated in the early Universe may still exist today. As the strings move across the sky, they produce, by gravitational lensing, a characteristic pattern of anisotropies in the temperature of the cosmic microwave background. The observed absence of such ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/335410a0
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  • 4
    Electronic Resource
    Electronic Resource
    Islet cell and insulin autoantibodies in subjects at high risk for development of Type 1 (insulin-dependent) diabetes mellitus: the Lyon family study (1988)
    Springer
    Diabetologia 31 (1988), S. 741-746 
    Details
    ISSN: 1432-0428
    Keywords: Prediction ; Type 1 (insulin-dependent) diabetes ; autoimmunity ; autoantibodies ; prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Genetic determination as well as prospective analysis of islet cell autoantibodies and autoantibodies to insulin were conducted in a population of 479 first degree relatives of 174 Type 1 (insulin-dependent) diabetic patients. Analysis of HLA haplotypes within families illustrated the high frequency of DR3 and DR4 alleles with preferential transmission from parent to both affected and unaffected offspring. DR4 was preferentially associated with DQw3.2 (TA10−) in 60/73 (82.2%) patients and 101/127 (79.5%) relatives. Relatives have been followed for a period of 800 subject-years. Twenty-two out of 430 relatives (5.1%) were found islet cell antibodies (ICA-IgG) positive. Seven sera with low titres became negative 6 months later at two different determinations. Fifteen sera ICA-IgG and ICA-protein A positive with high titres remained positive thereafter. Half of the ICA positive relatives were also found insulin autoantibodies (IAA) positive. All but 3 ICA negative relatives did not have IAA in their sera. Analysis of IAA specificity with competition experiments indicated that most antibodies recognised epitopes shared between human and pork insulins while four were specific for human insulin determinants. Analysis of class I and class II HLA antigen distribution indicated no particular allelic restriction in antibody positive individuals. Metabolic status of antibody positive relatives was determined with oral and intravenous charge of glucose. Two haplo-identical DR3-DQw2 brothers became diabetic during the study. One child and one mother both with DR4-DQw3.2 became intolerant to glucose. Each of these relatives had high titre ICA prior to metabolic deterioration. Taken together, these data indicated that ICA and IAA may be present in first degree relatives of diabetic patients. Individualisation of markers of the ongoing autoimmune process and accurate evaluation of the residual B-cell mass are necessary steps before further immune interventions in the early phases of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274776
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  • 5
    Electronic Resource
    Electronic Resource
    HLA-DR 3 is associated with a more slowly progressive form of Type 1 (insulin-dependent) diabetes (1986)
    Springer
    Diabetologia 29 (1986), S. 207-210 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; children ; HLA-types ; heterogeneity symptoms at onset ; partial remission ; genetic susceptibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1–19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR 2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented with Type 1 diabetes more evenly over the year; they also presented without incidence peaks at 7 years or 10–11 years, as seen especially in DR 3/4 patients. The DR 3 patients more often had mild disease with less ketonuria at diagnosis, less often ketoacidotic symptoms and more often a subsequent partial remission. The apparently more severe disease among diabetic girls may, at least to some extent, be explained by their higher prevalence of HLA-DR4. The differences found were similar in North America and Europe. The results suggest that Type 1 diabetes is a genetically heterogenous disease and that HLA-typing may be a useful marker of this heterogeneity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454876
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  • 6
    Electronic Resource
    Electronic Resource
    Dawn phenomenon in Type 1 (insulin-dependent) diabetic adolescents: influence of nocturnal growth hormone secretion (1988)
    Springer
    Diabetologia 31 (1988), S. 607-611 
    Details
    ISSN: 1432-0428
    Keywords: Dawn phenomenon ; Type 1 (insulin-dependent) diabetes ; adolescent ; growth hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to reassess the role of growth hormone in the dawn phenomenon, we studied eight C-peptide negative diabetic adolescents, who are likely to exhibit important nocturnal growth hormone surges. The insulin infusion rate necessary to maintain euglycaemia was predetermined in each patient from 22.00 hours to 01.00 hours, and then kept constant until 08.00 hours resulting in stable free insulin levels. Blood glucose rose from 4.3±0.7 mmol/l at 01.00 hours to 7.1±1.1 mmol/l at 08.00 hours (p〈0.01) secondary to an increased hepatic glucose production. All the subjects presented an important growth hormone secretion, ranging from 20 to 66 ng/ml (peak values) and from 3619 to 8621 ng·min· ml−1 (areas under the curve). The insulin infusion rate selected for each patient was positively correlated with the nocturnal growth hormone secretion (area under the curve) (r=0.87, p〈0.01). On the other hand, there was no relationship between the nocturnal growth hormone secretion and the magnitude of the early morning blood glucose rise (r=−0.48, p〉0.2). We conclude that, in Type 1 (insulin-dependent) diabetic adolescents, the dawn phenomenon exists but is moderate despite important growth hormone surges; the nocturnal growth hormone secretion influences the nocturnal insulin requirements but not the dawn phenomenon itself, if insulinisation is adequate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264768
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  • 7
    Electronic Resource
    Electronic Resource
    On the Picard group of Enriques surfaces (1985)
    Springer
    Mathematische Annalen 271 (1985), S. 577-600 
    Details
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01456135
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  • 8
    Electronic Resource
    Electronic Resource
    Localisation génétique et caractérisation biochimique de mutations affectant le gène de structure de l'hydrolyase altronique chez Escherichia coli K 12 (1972)
    Springer
    Molecular genetics and genomics 118 (1972), S. 335-350 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mutants of E. coli specifically deficient for the enzyme altronic hydrolyase have been isolated. These strains are unable to metabolize galacturonate but still normally grow on glucuronate; inducibility for the other galacturonate-induced enzymes is not modified. The position of these mutations called “uxaA” locus in relation to the argG, tolC and metC markers was established both by sexual crosses and by P1 transduction; evidence is presented that uxaA is located between argG and tolC. Biochemical characterization of uxaA mutants using thermosensible revertants or mutants was achieved by means of thermal inactivation and kinetic parameters determination. Experimental results strongly suggest that uxaA locus is the structural gene of the altronic hydrolyase enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333569
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  • 9
    Electronic Resource
    Electronic Resource
    Localisation génétique et caractérisation biochimique de mutations affectant le gène de structure de l'hydrolyase mannonique chez Escherichia coli K 12 (1972)
    Springer
    Molecular genetics and genomics 118 (1972), S. 351-362 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mutants of E. coli specifically deficient for the enzyme mannonic hydrolyase have been isolated. These strains are unable to metabolize glucuronate but still normally grow on galacturonate; inducibility for the other glucuronate-induced enzymes is not modified. The position of these mutations called “uxuA” locus in relation to the pyrB-guaC region, and probably near 85.5 minutes, was established by sexual crosses and by P1 transduction Biochemical characterization of uxuA mutants using thermosensible mutants was achieved by means of thermal inactivation and kinetic studies. Experimental results strongly suggest that uxuA locus is the structural gene of the mannonic hydrolyase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333570
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  • 10
    Electronic Resource
    Electronic Resource
    Long-range proton—carbon-13 coupling constants of monosaccharides by selective heteronuclear 2D-J NMR spectroscopy (1988)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 26 (1988), S. 264-270 
    Details
    ISSN: 0749-1581
    Keywords: 2D-J NMR heteronuclear spectroscopy ; Selective irradiation ; Long-range Proton—Carbon couplings ; Glycoside derivatives ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Long-range J(CH) values were measured for six glycoside derivatives by a selective 2D-J heteronuclear sequence. The values obtained are discussed in terms of conformational effects and constitute a valuable contribution to 2J and 3J comprehension.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260260316
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