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  • Primary aldosteronism  (2)
  • 1985-1989  (1)
  • 1970-1974  (1)
  • 1965-1969
  • 1940-1944
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 361-363 
    ISSN: 1432-1440
    Keywords: Primary aldosteronism ; Captopril ; Spironolactone ; Renin-angiotensin ; Converting-enzyme ; Secondary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In three patients with primary aldosteronism, the acute effect of a single dose of captopril on the elevated mean arterial blood pressure (MAP) was studied before and after 4 weeks of treatment with spironolactone. Before spironolactone therapy, captopril did not cause any drop in MAP. Four weeks later, after an oral daily dose of 400 mg spironolactone, MAP was still elevated in all three patients, though electrolyte abnormalities were fully corrected. Since plasma renin activity (PRA) was increased to values above the normal range, the acute effect of captopril on MAP was tested again. A single dose of 25 mg captopril then caused a fall in MAP to normal. These data reveal the conversion from a renin-independent to a renindependent kind of hypertension after spironolactone therapy in three patients with primary aldosteronism syndrome. This might be of pathogenetic and therapeutic interest.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Primary aldosteronism ; Plasma renin concentration ; Primärer Hyperaldosteronismus ; Plasma-Renin-Konzentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 13 Patienten mit einem primären Hyperaldosteronismus wurde die Plasma-Renin-Konzentration unter Stimulations- und unter Suppressionsbedingungen gemessen. Eine hochempfindliche Methode zur Reninmessung, die sich eines Radioimmunoassays für Angiotensin I bediente, wurde verwandt. Bei jedem der Patienten ließ sich die Reninkonzentration im Plasma gut messen. Die Werte lagen hochsignifikant unter den Normbereichen, die unter denselben Bedingungen ermittelt worden waren. Am eindrücklichsten war der Unterschied zwischen normalen und pathologischen Werten unter Stimulationsbedingungen. Nach Kochsalzentzug stieg die Reninkonzentration zwar bei nahezu allen Patienten signifikant an, der Anstieg war jedoch subnormal, gemessen an dem gesunden Kontrollkollektiv. Renin ist auch beim primären Aldosteronismus im Plasma vorhanden und reagiert auf Stimulation qualitativ regelrecht, quantitativ jedoch subnormal.
    Notes: Summary Plasma renin concentration (PRC) was measured in thirteen patients with primary aldosteronism during high and low sodium intake. A highly sensitive method using a radioimmunoassay for angiotensin I was applied for the determinations of PRC. PRC was detectable in each patient. The values obtained were significantly lower than the normal ranges which were assessed under the same conditions. Most impressive was the difference between normal and pathological values during sodium deprivation. PRC rose in almost each patient after several days of dietary sodium restriction. The increase was subnormal, however, when compared with normal controls. Renin is present in plasma of patients with primary aldosteronism. It responds qualitatively normally, but quantitatively subnormally when stimulated by sodium deprivation.
    Type of Medium: Electronic Resource
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