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  • 1
    Electronic Resource
    Electronic Resource
    Normal sister chromatid exchange in lymphocytes from patients with multiple epidermal cancer? (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 180-183 
    Details
    ISSN: 1432-069X
    Keywords: Multiple epidermal cancer ; Sister chromatid exchange ; Lymphocyte UVC sensitivity ; Lymphocyte X-ray sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Exposure to toxins in the environment and due to personal habits, e. g., tobacco smoking, may increase the rate of spontaneous sister chromatid exchange (SCE). The SCE in lymphocytes from a group of 31 patients with multiple epidermal cancer, who in the past had been exposed to various skin carcinogens, as a whole exceeded that of a control group — matched by sex, age, and smoking habits — but the difference was not statistically significant (p=0.08). The individual SCE in these patients was also statistically independent of the nature of the carcinogenic exposure. We were unable to detect correlations between the SCE and UVC-radiation induced DNA synthesis, UVC-radiation tolerance, or rate of X-ray damage repair. This suggests that the molecular mechanisms involved in SCE induction and in repair of radiation damage are basically independent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413254
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  • 2
    Electronic Resource
    Electronic Resource
    Toxic Effects of 8-Methoxypsoralen on Lymphocyte Devision (1977)
    Springer
    Archives of dermatological research 260 (1977), S. 87-92 
    Details
    ISSN: 1432-069X
    Keywords: Lymphocyte growth ; Psoralen ; Cell culture ; UVA action ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gezüchtete humane Leukocyten sind für die Untersuchung der Toxicität und der Phototoxicität des 8-Methoxy-Psoralen (8-MOP) verwendet worden. Man hat festgestellt, daß 8-MOP in einer Konzentration von mehr als 10−10 M die Zellteilung hemmt. Bei 8-MOP und black light (UVA) fängt die Hemmung bei 10−14 M an. Bei Patienten, die wegen Psoriasis mit 8-MOP behandelt werden, zeigen sich Konzentrationen von 10−6-10−7 M. Die mit der hier angewendeten Technik festgestellten Hemmung der Zellteilung beträgt bei dieser Konzentration für 8-MOP allein 40% und für 8-MOP + UVA 70%. Diese Ergebnisse sind mit dem Befund an Mikronuclei und Chromosomabnormalitäten in sich teilenden Zellen in Zusammenhang zu sehen.
    Notes: Summary Cultured human leucocytes have been used to examine the toxicity and phototoxicity of 8-methoxy psoralen (8-MOP). It has been shown that 8-MOP depresses cell turnover at concentrations of 10−10 M or above. In black light (UVA), 8-MOP inhibition begins at concentrations of 10−14 M. Patients treated for psoriasis with 8-MOP show concentrations of 10−6-10−7 M. The inhibition of cell turnover observed with the present technique is at this concentration 40% for 8-MOP alone and 70% for 8-MOP and black light. These results can be related to the micronuclei and chromosome abnormalities seen in dividing cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561113
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  • 3
    Electronic Resource
    Electronic Resource
    Acute effect of 8-methoxypsoralen and ultraviolet light on sister chromatid exchange (1978)
    Springer
    Archives of dermatological research 263 (1978), S. 37-46 
    Details
    ISSN: 1432-069X
    Keywords: Sister chromatid exchange ; 8-MOP ; ultraviolet light ; Schwester-chromatiden-Austausch ; 8-MOP, langwelliges UV-Licht
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die unmittelbare Wirkung von 8-Methoxypsoralen (8-MOP) sowie von 8-MOP+langwelligem UV-Licht (UVA) auf Schwesterchromatiden-Austausch (SCE) wurde in einem in vitro-Experiment untersucht. Der SCE nach 8-MOP allein war signifikant erhöht, aber die Wirkung war wesentlich größer (50%) nach der Behandlung mit 8-MOP+UVA. Dazu wurden nach der Behandlung mit 8-MOP-Mitosen mit «gestreifter» Färbung der Chromosomen beobachtet. Die Veränderungen sind dosisabhängig und bilden möglicherweise die Ursache für die nach PUVA-Behandlung verminderte Zellteilung in Psoriasisflecken.
    Notes: Summary The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP+long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP+UVA. In addition, mitoses with banded staining of the chromosomes were seen after 8-MOP and UVA. These changes were dose dependent, and they might be responsible for the reduced cell turnover in psoriasis plaque after PUVA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446852
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  • 4
    Electronic Resource
    Electronic Resource
    Occupational chronic exposure to organic solvents XI. Alkylbenzene exposure of varnish workers: effects on hematopoetic system (1985)
    Springer
    International archives of occupational and environmental health 56 (1985), S. 307-321 
    Details
    ISSN: 1432-1246
    Keywords: Xylenes ; Ethylbenzene ; Spraymen ; Blood levels ; Metabolite ; Excretion ; Changes in blood cell counts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-five spraymen, who were varnishing vehicles with alkyd-, phenol- and polyestervarnishes, which were dissolved in solvent mixtures mainly containing o-, m-, p-xylene and ethylbenzene, have been investigated. The concentrations of these solvents in air were 2.1, 7.9, 2.8 and 4.0 ppm on average. The levels of alkylbenzenes in blood and those of their metabolites in urine have been determined. At two of the six working places the spraymen were additionally exposed to n-butanol, respectively 1,1,1-trichloroethane, and several C9-aromatic hydrocarbons. Some of the lacquers contained lead pigments. Alterations of blood cell counts have been observed under the described conditions of exposure. On average the number of lymphocytes was higher than that of segmented granulocytes. Erythrocytes and hemoglobin level of the spraymen were lower than those of the controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405272
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  • 5
    Electronic Resource
    Electronic Resource
    In vitro fertilization (IVF)-surrogacy: Application of IVF to women without functional uteri (1989)
    Springer
    Journal of assisted reproduction and genetics 6 (1989), S. 134-137 
    Details
    ISSN: 1573-7330
    Keywords: in vitro fertilization (IVF)-surrogacy ; surrogate host ; hysterectomy ; mullerian dysgenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Women with absent or dysfunctional uteri consented to controlled ovarian stimulation, ovum aspiration, in vitro fertilization, and embryo culture. Cleaving preembryos were transferred to recipient (surrogate) women whose menstrual cycles were in approximate synchrony with the ovum donor. None of the embryo recipients received medication. Six cases are described, resulting in one spontaneous loss at 6 weeks, four full-term deliveries, and one ongoing pregnancy. HLA typing demonstrated all babies to be genotypic offspring of the gamete donors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01130776
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  • 6
    Electronic Resource
    Electronic Resource
    Surrogate gestational carriers (1989)
    Springer
    Journal of assisted reproduction and genetics 6 (1989), S. 188-188 
    Details
    ISSN: 1573-7330
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01130787
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  • 7
    Electronic Resource
    Electronic Resource
    Comparison of a fluorescent monoclonal antibody assay and a tissue culture assay for routine detection of infections caused byChlamydia trachomatis (1986)
    Springer
    European journal of clinical microbiology & infectious diseases 5 (1986), S. 554-558 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The applicability of a commercial direct immunofluorescent monoclonal antibody assay for detection of Chlamydia trachomatis elementary bodies was studied on endocervical smears from 506 women attending a venereal disease clinic. The aim of this prospective examination was to simulate a daily routine. The results were compared to those of a well-functioning tissue culture assay. The overall positivity was 22.7 %. Based on a positivity criterion of ⩾ 1 elementary body in the fluorescent antibody assay, the two assays agreed in 84.8 % of the cases. In 50 specimens the antibody assay was positive and the culture assay negative, whereas in 23 the culture assay was positive and the antibody assay negative. The positive predictive value was 63.8 %. Most of the discrepancies were found in specimens containing few elementary bodies or inclusions. Based on a criterion of ⩾ 10 elementary bodies, the positive predictive value was 70.9 %, but the sensitivity fell to 67.5 %.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02017704
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