ISSN:
0935-6304
Keywords:
Gas chromatography
;
Capillary, nickel
;
„Transevaporator“ into packed pre-column as sampling technique prior capillary described
;
Application to volatile metabolite body fluid analysis for early detection of disease
;
Serum and human breast milk as examples
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Nickel capillary columns coated with moderately polarstationary phases such as Witconol can be used for the separation of the organic volatile fraction from biological fluids. A “transevaporator” sampling technique for the collection of the organic volatiles on glass beads from as little as 5 to 500 μl of biological fluids (e.g. urine, serum, amniotic fluid, breast milk, saliva, etc.) is described. The organic volatiles are thermally desorbed from the glass beads into a short precolumn cooled in liquid nitrogen, which overcomes the problems associated with sample introduction onto narrow-bore capillary columns. The application of the full analytical technique to problems associated with the early detection of disease is illustrated.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240020710
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